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    Fxyd5 FXYD domain-containing ion transport regulator 5 [ Mus musculus (house mouse) ]

    Gene ID: 18301, updated on 26-Jun-2015
    Official Symbol
    Fxyd5provided by MGI
    Official Full Name
    FXYD domain-containing ion transport regulator 5provided by MGI
    Primary source
    MGI:MGI:1201785
    See related
    Ensembl:ENSMUSG00000009687; Vega:OTTMUSG00000034687
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RIC; EF-8; Oit2
    Summary
    This gene encodes a precursor protein that is member of the FXYD family of transmembrane glycoproteins. Like most members of the FXYD family, the encoded protein is a subunit of the sodium-potassium adenosine triphosphatase pump. FXYD family members have tissue-specific expression and differentially regulate the activity of this pump. The protein encoded by this gene also plays a role in cell adhesion and motility. The orthologous human protein inhibits epithelial cadherin, a calcium-dependent adhesion protein and is associated with cancer (promotes metastasis). Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Dec 2013]
    Orthologs
    See Fxyd5 in Epigenomics, MapViewer
    Location:
    7; 7 B1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (31032723..31042331, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (31817742..31827341, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187, member B Neighboring gene olfactory receptor 1359 pseudogene Neighboring gene predicted gene, 42377 Neighboring gene predicted gene, 38984 Neighboring gene microRNA 7050 Neighboring gene FXYD domain-containing ion transport regulator 7 Neighboring gene FXYD domain-containing ion transport regulator 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    FXYD domain-containing ion transport regulator 5
    Names
    FXYD domain-containing ion transport regulator 5
    dysadherin
    ion channel homolog RIC
    oncoprotein induced transcript 2
    oncoprotein-induced protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111073.2NP_001104543.1  FXYD domain-containing ion transport regulator 5 isoform a precursor

      See identical proteins and their annotated locations for NP_001104543.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC149055, AK155763, BY574553
      Consensus CDS
      CCDS21121.1
      UniProtKB/Swiss-Prot
      P97808
      UniProtKB/TrEMBL
      Q3TDW1
      Related
      ENSMUSP00000125398, OTTMUSP00000047975, ENSMUST00000161805, OTTMUST00000088060
      Conserved Domains (1) summary
      pfam02038
      Location:130167
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
    2. NM_001287213.1NP_001274142.1  FXYD domain-containing ion transport regulator 5 isoform a precursor

      See identical proteins and their annotated locations for NP_001274142.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC149055
      Consensus CDS
      CCDS21121.1
      UniProtKB/Swiss-Prot
      P97808
      UniProtKB/TrEMBL
      Q3TDW1
      Conserved Domains (1) summary
      pfam02038
      Location:130167
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
    3. NM_001287217.1NP_001274146.1  FXYD domain-containing ion transport regulator 5 isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded protein (isoform b) is longer than isoform a.
      Source sequence(s)
      AC149055
      Consensus CDS
      CCDS71935.1
      UniProtKB/TrEMBL
      F8WJA1
      Related
      ENSMUSP00000009831, OTTMUSP00000047999, ENSMUST00000009831, OTTMUST00000088101
      Conserved Domains (1) summary
      pfam02038
      Location:131168
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
    4. NM_008761.4NP_032787.1  FXYD domain-containing ion transport regulator 5 isoform a precursor

      See identical proteins and their annotated locations for NP_032787.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC149055, AI121044, AK003068, BY574553
      Consensus CDS
      CCDS21121.1
      UniProtKB/Swiss-Prot
      P97808
      UniProtKB/TrEMBL
      Q3TDW1
      Related
      ENSMUSP00000125285, OTTMUSP00000047974, ENSMUST00000161684, OTTMUST00000088059
      Conserved Domains (1) summary
      pfam02038
      Location:130167
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

      Range
      31032723..31042331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      25600304..25609858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)