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    Mt1 metallothionein 1 [ Mus musculus (house mouse) ]

    Gene ID: 17748, updated on 27-Jun-2015
    Official Symbol
    Mt1provided by MGI
    Official Full Name
    metallothionein 1provided by MGI
    Primary source
    MGI:MGI:97171
    See related
    Ensembl:ENSMUSG00000031765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MT-I; Mt-1
    Location:
    8 C5; 8 46.34 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (94179088..94180327)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (96702989..96704227)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39227 Neighboring gene metallothionein 2 Neighboring gene predicted gene, 39228 Neighboring gene nucleoporin 93 Neighboring gene ribosomal protein L10, pseudogene 5

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Mineral absorption, organism-specific biosystem (from KEGG)
      Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
    • Mineral absorption, conserved biosystem (from KEGG)
      Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
    • Oxidative Stress, organism-specific biosystem (from WikiPathways)
      Oxidative Stress, organism-specific biosystem
      Oxidative Stress
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular metal ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to chromate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to zinc ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detoxification of copper ion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nitric oxide mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    metallothionein-1
    Names
    metallothionein-1
    metallothionein-I

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013602.3NP_038630.1  metallothionein-1

      See identical proteins and their annotated locations for NP_038630.1

      Status: VALIDATED

      Source sequence(s)
      AA050166, AC131733, AK018727
      Consensus CDS
      CCDS40438.1
      UniProtKB/Swiss-Prot
      P02802
      Related
      ENSMUSP00000034215, ENSMUST00000034215
      Conserved Domains (1) summary
      pfam00131
      Location:559
      Metallothio; Metallothionein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

      Range
      94179088..94180327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530752.2XP_006530815.1  

      See identical proteins and their annotated locations for XP_006530815.1

      UniProtKB/TrEMBL
      Q8R074
      Conserved Domains (1) summary
      pfam00131
      Location:532
      Metallothio; Metallothionein

    Alternate Mm_Celera

    Genomic

    1. AC_000030.1 Alternate Mm_Celera

      Range
      98511203..98512441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)