Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    Mep1b meprin 1 beta [ Mus musculus (house mouse) ]

    Gene ID: 17288, updated on 26-Jun-2015
    Official Symbol
    Mep1bprovided by MGI
    Official Full Name
    meprin 1 betaprovided by MGI
    Primary source
    MGI:MGI:96964
    See related
    Ensembl:ENSMUSG00000024313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mep-1b
    Orthologs
    See Mep1b in Epigenomics, MapViewer
    Location:
    18 A2; 18 11.81 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (21072344..21100199)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (21230845..21258700)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene ring finger protein 125 Neighboring gene ring finger protein 138 Neighboring gene ribosomal protein L27A pseudogene Neighboring gene GRB2 associated, regulator of MAPK1 Neighboring gene predicted gene 7758

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...

    Markers

    Homology

    Clone Names

    • MGC159330

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    meprin A subunit beta
    Names
    meprin A subunit beta
    endopeptidase-2
    meprin B
    meprin beta
    NP_032612.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008586.2NP_032612.2  meprin A subunit beta precursor

      See identical proteins and their annotated locations for NP_032612.2

      Status: VALIDATED

      Source sequence(s)
      AK098127
      Consensus CDS
      CCDS37747.1
      UniProtKB/Swiss-Prot
      Q61847
      Related
      ENSMUSP00000080866, ENSMUST00000082235
      Conserved Domains (6) summary
      cd06263
      Location:266428
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      cd00054
      Location:609647
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00629
      Location:266429
      MAM; MAM domain
      pfam01400
      Location:70258
      Astacin; Astacin (Peptidase family M12A)
      cl02446
      Location:428587
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl00064
      Location:30256
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

      Range
      21072344..21100199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000040.1 Alternate Mm_Celera

      Range
      21568002..21595856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)