Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 [ Homo sapiens (human) ]

    Gene ID: 153201, updated on 27-Jun-2015
    Official Symbol
    SLC36A2provided by HGNC
    Official Full Name
    solute carrier family 36 (proton/amino acid symporter), member 2provided by HGNC
    Primary source
    HGNC:HGNC:18762
    See related
    Ensembl:ENSG00000186335; HPRD:12215; MIM:608331; Vega:OTTHUMG00000130129
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAT2; TRAMD1
    Summary
    This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]
    Orthologs
    See SLC36A2 in Epigenomics, MapViewer
    Location:
    5q33.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (151314978..151347590, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150694539..150727151, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene GM2 ganglioside activator Neighboring gene solute carrier family 36, member 3 Neighboring gene ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 pseudogene 5 Neighboring gene uncharacterized LOC105378234 Neighboring gene mediator complex subunit 13 pseudogene Neighboring gene RUN domain containing 1 pseudogene

    Markers

    Homology

    Clone Names

    • FLJ16051, MGC119658, MGC119660

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    L-alanine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    L-proline transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glycine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrogen ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    hydrogen:amino acid symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    L-alanine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    amino acid transport TAS
    Traceable Author Statement
    more info
     
    glycine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    hydrogen ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ion transport TAS
    Traceable Author Statement
    more info
     
    proline transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    proton-coupled amino acid transporter 2
    Names
    proton-coupled amino acid transporter 2
    tramdorin-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027745.1 RefSeqGene

      Range
      5001..37613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_181776.2NP_861441.2  proton-coupled amino acid transporter 2

      See identical proteins and their annotated locations for NP_861441.2

      Status: REVIEWED

      Source sequence(s)
      AC008385, AY162214, BC101101, DC362112
      Consensus CDS
      CCDS4315.1
      UniProtKB/Swiss-Prot
      Q495M3
      Related
      ENSP00000334223, OTTHUMP00000160624, ENST00000335244, OTTHUMT00000252437
      Conserved Domains (1) summary
      cl00456
      Location:52463
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

      Range
      151314978..151347590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714756.2XP_006714819.1  

      Conserved Domains (1) summary
      cl00456
      Location:52430
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_005268377.3XP_005268434.1  

      Conserved Domains (1) summary
      cl00456
      Location:52365
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. XM_011537559.1XP_011535861.1  

      Conserved Domains (1) summary
      cl00456
      Location:52281
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      150127312..150159946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)