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    Fgf12 fibroblast growth factor 12 [ Mus musculus (house mouse) ]

    Gene ID: 14167, updated on 26-Jun-2015
    Official Symbol
    Fgf12provided by MGI
    Official Full Name
    fibroblast growth factor 12provided by MGI
    Primary source
    MGI:MGI:109183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fhf1; FHF-1; FGF-12; AV114868; B230343J05Rik
    Orthologs
    See Fgf12 in Epigenomics, MapViewer
    Location:
    16 19.38 cM; 16 B1-B3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (28157783..28753243, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (28160184..28753288, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 106 pseudogene Neighboring gene predicted gene 10823 Neighboring gene predicted gene, 41438 Neighboring gene predicted gene, 41437 Neighboring gene microRNA 690 Neighboring gene 60S ribosomal protein L26-like Neighboring gene Mab-21 domain containing 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
      ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
      Regulation of Actin Cytoskeleton, organism-specific biosystem
      Regulation of Actin Cytoskeleton
    • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
      Regulation of actin cytoskeleton, organism-specific biosystem
      Regulation of actin cytoskeleton
    • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
      Regulation of actin cytoskeleton, conserved biosystem
      Regulation of actin cytoskeleton

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    sodium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    adult locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NOT fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    neuromuscular process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of sodium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    fibroblast growth factor 12
    Names
    fibroblast growth factor 12
    fibroblast growth factor homologous factor 1
    myocyte-activating factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276419.2NP_001263348.1  fibroblast growth factor 12 isoform c

      See identical proteins and their annotated locations for NP_001263348.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon structure, differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform c which is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC154619, AC154656, AC154663, AK011712, AK034150, AK034335, AK046130, BY477982
      UniProtKB/Swiss-Prot
      P61329
      Conserved Domains (1) summary
      cd00058
      Location:40166
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
    2. NM_001276420.1NP_001263349.1  fibroblast growth factor 12 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' exon structure and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform d which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC154663, AK018774, AK148215, BP768136
      UniProtKB/TrEMBL
      Q3UFZ2
      Conserved Domains (1) summary
      cl00060
      Location:73105
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
    3. NM_010199.4NP_034329.1  fibroblast growth factor 12 isoform b

      See identical proteins and their annotated locations for NP_034329.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' exon structure, differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform b which is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AC154619, AK034150, AK034335, AK046130, BB611389, BY477982, CX239635
      UniProtKB/Swiss-Prot
      P61329
      Conserved Domains (1) summary
      cd00058
      Location:14140
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
    4. NM_183064.5NP_898887.1  fibroblast growth factor 12 isoform a

      See identical proteins and their annotated locations for NP_898887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC154619, AC154663, AK034150, AK034335, AK046130, AK148215, BY477982
      Consensus CDS
      CCDS28092.1
      UniProtKB/Swiss-Prot
      P61329
      UniProtKB/TrEMBL
      Q3UFZ2
      Conserved Domains (1) summary
      cd00058
      Location:76202
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

      Range
      28157783..28753243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521793.2XP_006521856.1  

      See identical proteins and their annotated locations for XP_006521856.1

      Conserved Domains (1) summary
      cd00058
      Location:1116
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

    Alternate Mm_Celera

    Genomic

    1. AC_000038.1 Alternate Mm_Celera

      Range
      28678505..29265487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)