Dyrk1a dual-specificity tyrosine phosphorylation regulated kinase 1a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dyrk1aprovided by MGI
Official Full Name: dual-specificity tyrosine phosphorylation regulated kinase 1aprovided by MGI
Primary source: MGI:MGI:1330299
See related: Ensembl:ENSMUSG00000022897 AllianceGenome:MGI:1330299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mmb; Dyrk; Mnbh; Mp86; Gm10783; D16Ertd272e; D16Ertd493e; 2310043O08Rik
Summary: Enables several functions, including identical protein binding activity; protein self-association; and tau protein binding activity. Involved in several processes, including negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of microtubule polymerization; and protein phosphorylation. Acts upstream of or within negative regulation of mRNA splicing, via spliceosome and peptidyl-tyrosine phosphorylation. Located in several cellular components, including axon; cytoskeleton; and dendrite. Part of ribonucleoprotein complex. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study Down syndrome. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 12.2), whole brain E14.5 (RPKM 10.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 55.3 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (94370770..94496378)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (94569947..94695519)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes.
Title: MicroRNA-221-3p inhibits the inflammatory response of keratinocytes by regulating the DYRK1A/STAT3 signaling pathway to promote wound healing in diabetes.
miRNA-192-5p targets Dyrk1a to attenuate cerebral injury in MCAO mice by suppressing neuronal apoptosis and neuroinflammation.
Title: miRNA-192-5p targets Dyrk1a to attenuate cerebral injury in MCAO mice by suppressing neuronal apoptosis and neuroinflammation.
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.
Title: Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome.
Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A.
Title: Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A.
Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model.
Title: Sex-specific developmental alterations in DYRK1A expression in the brain of a Down syndrome mouse model.
Haploid-genetic screening of trophectoderm specification identifies Dyrk1a as a repressor of totipotent-like status.
Title: Haploid-genetic screening of trophectoderm specification identifies Dyrk1a as a repressor of totipotent-like status.
Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice.
Title: Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice.
An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.
Title: An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.
Deletion of DYRK1A Accelerates Osteoarthritis Progression Through Suppression of EGFR-ERK Signaling.
Title: Deletion of DYRK1A Accelerates Osteoarthritis Progression Through Suppression of EGFR-ERK Signaling.
Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes.
Title: Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes.

Submit: New GeneRIF Correction See all GeneRIFs (100)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (6) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dyrk1a (e-PCR), detects polymorphism
- UniSTS:530945

Dyrk1a (e-PCR), detects polymorphism
- UniSTS:259077

RH126831 (e-PCR)
- UniSTS:167185

AU021758 (e-PCR)
- UniSTS:167192

Dyrk1a (e-PCR), detects polymorphism
- UniSTS:259608

AI324963 (e-PCR)
- UniSTS:160601

Dyrk1a (e-PCR), detects polymorphism
- UniSTS:142938

Dyrk1a (e-PCR), detects polymorphism
- UniSTS:536448

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables histone H3T45 kinase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables tau protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA methylation-dependent heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein deacetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with actin filament	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
colocalizes_with neurofilament	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dual specificity tyrosine-phosphorylation-regulated kinase 1A

Names: dual specificity YAK1-related kinase; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a; protein kinase minibrain homolog

NP_001106860.1

EC 2.7.11.23

EC 2.7.12.1

NP_001334660.1

EC 2.7.11.23

EC 2.7.12.1

NP_001389720.1

EC 2.7.11.23

EC 2.7.12.1

NP_001389721.1

EC 2.7.11.23

EC 2.7.12.1

NP_001389722.1

EC 2.7.11.23

EC 2.7.12.1

NP_031916.1

EC 2.7.11.23

EC 2.7.12.1

XP_011244397.1

EC 2.7.11.23

EC 2.7.12.1

XP_036015668.1

EC 2.7.11.23

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113389.1 → NP_001106860.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

See identical proteins and their annotated locations for NP_001106860.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 5' non-coding exon, therefore, has a different 5' UTR compared to transcript variant 1. Transcript variants 1 and 2 encode the same protein.

Source sequence(s)

AK052390, AK163136, BC129888, CB526389, CX566606

Consensus CDS

CCDS28350.1

UniProtKB/Swiss-Prot

Q61214

UniProtKB/TrEMBL

A9C475

Related

ENSMUSP00000023614.5, ENSMUST00000023614.5

Conserved Domains (1) summary

cd14226
Location:148 → 484

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
NM_001347731.2 → NP_001334660.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2

Status: VALIDATED

Source sequence(s)

AC165271, CT030190

UniProtKB/TrEMBL

A1L341

Conserved Domains (1) summary

cd14226
Location:139 → 475

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
NM_001402791.1 → NP_001389720.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

Status: VALIDATED

Source sequence(s)

AC165271, CT030190

UniProtKB/Swiss-Prot

Q61214

UniProtKB/TrEMBL

A9C475
NM_001402792.1 → NP_001389721.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 3

Status: VALIDATED

Source sequence(s)

AC165271, CT030190
NM_001402793.1 → NP_001389722.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 4

Status: VALIDATED

Source sequence(s)

AC165271, CT030190

UniProtKB/TrEMBL

F6U6X3

Related

ENSMUSP00000112853.3, ENSMUST00000122284.9
NM_007890.2 → NP_031916.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

See identical proteins and their annotated locations for NP_031916.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Transcript variants 1 and 2 encode the same protein.

Source sequence(s)

AK052390, AK163136, BC129888, BF462682, CD540384, CX566606

Consensus CDS

CCDS28350.1

UniProtKB/Swiss-Prot

Q61214

UniProtKB/TrEMBL

A9C475

Related

ENSMUSP00000113660.2, ENSMUST00000119878.8

Conserved Domains (1) summary

cd14226
Location:148 → 484

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

94370770..94496378

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159775.1 → XP_036015668.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2

UniProtKB/TrEMBL

A1L341

Conserved Domains (1) summary

cd14226
Location:139 → 475

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
XM_011246095.4 → XP_011244397.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

See identical proteins and their annotated locations for XP_011244397.1

UniProtKB/Swiss-Prot

Q61214

UniProtKB/TrEMBL

A9C475

Conserved Domains (1) summary

cd14226
Location:148 → 484

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1