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    Col18a1 collagen, type XVIII, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 12822, updated on 27-Jun-2015
    Official Symbol
    Col18a1provided by MGI
    Official Full Name
    collagen, type XVIII, alpha 1provided by MGI
    Primary source
    MGI:MGI:88451
    See related
    Ensembl:ENSMUSG00000001435; Vega:OTTMUSG00000021408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    See Col18a1 in Epigenomics, MapViewer
    Location:
    10 B5-C1; 10 39.72 cM
    Exon count:
    44
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (77052178..77166530, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (76514924..76629275, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene 10787 Neighboring gene predicted gene, 3137 Neighboring gene solute carrier family 19 (folate transporter), member 1 Neighboring gene spermidine synthase pseudogene Neighboring gene predicted gene, 35837 Neighboring gene predicted gene, 40704 Neighboring gene predicted gene, 40703

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    endothelial cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    collagen alpha-1(XVIII) chain
    Names
    collagen alpha-1(XVIII) chain
    endostatin
    procollagen, type XVIII, alpha 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109991.1NP_001103461.1  collagen alpha-1(XVIII) chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_001103461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159334, BC064817, CF171159
      Consensus CDS
      CCDS48604.1
      UniProtKB/Swiss-Prot
      P39061
      Related
      ENSMUSP00000101049, OTTMUSP00000023766, ENSMUST00000105409, OTTMUST00000050740
      Conserved Domains (4) summary
      pfam01391
      Location:822881
      Collagen; Collagen triple helix repeat (20 copies)
      cd00110
      Location:281429
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00247
      Location:13501520
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      pfam06121
      Location:22219
      DUF959; Domain of Unknown Function (DUF959)
    2. NM_009929.3NP_034059.2  collagen alpha-1(XVIII) chain isoform 2 precursor

      See identical proteins and their annotated locations for NP_034059.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. These variations cause translation initiation from a start codon in a different exon and result in a shorter protein (isoform 2) with a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      BC064817, CF171159, U11636
      Consensus CDS
      CCDS23953.1
      UniProtKB/Swiss-Prot
      P39061
      Related
      ENSMUSP00000080358, OTTMUSP00000023764, ENSMUST00000081654, OTTMUST00000050738
      Conserved Domains (3) summary
      pfam01391
      Location:610669
      Collagen; Collagen triple helix repeat (20 copies)
      smart00210
      Location:33221
      TSPN; Thrombospondin N-terminal -like domains
      cd00247
      Location:11381308
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

      Range
      77052178..77166530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513175.2XP_006513238.1  

      Conserved Domains (5) summary
      cd07455
      Location:366488
      CRD_Collagen_XVIII; Cysteine-rich domain of the variant 3 of collagen XVIII (V3C18 )
      pfam01391
      Location:10691128
      Collagen; Collagen triple helix repeat (20 copies)
      cd00110
      Location:528676
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00247
      Location:15861756
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      pfam06121
      Location:22219
      DUF959; Domain of Unknown Function (DUF959)
    2. XM_006513174.2XP_006513237.1  

      Conserved Domains (5) summary
      cd07455
      Location:366488
      CRD_Collagen_XVIII; Cysteine-rich domain of the variant 3 of collagen XVIII (V3C18 )
      pfam01391
      Location:10691128
      Collagen; Collagen triple helix repeat (20 copies)
      cd00110
      Location:528676
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00247
      Location:15961766
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      pfam06121
      Location:22219
      DUF959; Domain of Unknown Function (DUF959)
    3. XM_006513173.2XP_006513236.1  

      UniProtKB/TrEMBL
      E9QPX1
      Related
      ENSMUSP00000072538, ENSMUST00000072755
      Conserved Domains (5) summary
      cd07455
      Location:366488
      CRD_Collagen_XVIII; Cysteine-rich domain of the variant 3 of collagen XVIII (V3C18 )
      pfam01391
      Location:10691128
      Collagen; Collagen triple helix repeat (20 copies)
      cd00110
      Location:528676
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00247
      Location:15971767
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      pfam06121
      Location:22219
      DUF959; Domain of Unknown Function (DUF959)
    4. XM_006513176.2XP_006513239.1  

      Conserved Domains (4) summary
      pfam01391
      Location:822881
      Collagen; Collagen triple helix repeat (20 copies)
      cd00110
      Location:281429
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      cd00247
      Location:13491519
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      pfam06121
      Location:22219
      DUF959; Domain of Unknown Function (DUF959)
    5. XM_011243346.1XP_011241648.1  

      Conserved Domains (5) summary
      pfam01391
      Location:778837
      Collagen; Collagen triple helix repeat (20 copies)
      smart00210
      Location:201389
      TSPN; Thrombospondin N-terminal -like domains
      cd00247
      Location:13061476
      Endostatin-like; Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; ...
      pfam06482
      Location:11671483
      Endostatin; Collagenase NC10 and Endostatin
      cl02447
      Location:93197
      CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
    6. XM_011243347.1XP_011241649.1  

      Conserved Domains (4) summary
      cd07455
      Location:366488
      CRD_Collagen_XVIII; Cysteine-rich domain of the variant 3 of collagen XVIII (V3C18 )
      pfam01391
      Location:840875
      Collagen; Collagen triple helix repeat (20 copies)
      cd00110
      Location:528676
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam06121
      Location:22219
      DUF959; Domain of Unknown Function (DUF959)

    Alternate Mm_Celera

    Genomic

    1. AC_000032.1 Alternate Mm_Celera

      Range
      78096179..78210613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)