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    Cfl1 cofilin 1, non-muscle [ Mus musculus (house mouse) ]

    Gene ID: 12631, updated on 27-Jun-2015
    Official Symbol
    Cfl1provided by MGI
    Official Full Name
    cofilin 1, non-muscleprovided by MGI
    Primary source
    MGI:MGI:101757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cof; AA959946; n-cofilin
    Orthologs
    See Cfl1 in Epigenomics, MapViewer
    Location:
    19; 19 A
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (5490455..5494031)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (5490455..5494031)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene epidermal growth factor-containing fibulin-like extracellular matrix protein 2 Neighboring gene MUS81 endonuclease homolog (yeast) Neighboring gene RIKEN cDNA 1700020D05 gene Neighboring gene sorting nexin 32 Neighboring gene predicted gene, 31166 Neighboring gene OVO homolog-like 1 (Drosophila)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin filament depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell projection organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    movement of cell or subcellular component IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural fold formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of actin filament depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    response to amino acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cofilin-1
    Names
    cofilin-1
    cofilin, non-muscle isoform

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007687.5NP_031713.1  cofilin-1

      See identical proteins and their annotated locations for NP_031713.1

      Status: VALIDATED

      Source sequence(s)
      AI844923, BC058726, CX218255
      UniProtKB/Swiss-Prot
      P18760
      UniProtKB/TrEMBL
      Q544Y7
      Conserved Domains (1) summary
      cd11286
      Location:3153
      ADF_cofilin_like; Cofilin, Destrin, and related actin depolymerizing factors

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

      Range
      5490455..5494031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000041.1 Alternate Mm_Celera

      Range
      5362154..5365730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)