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    Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 [ Mus musculus (house mouse) ]

    Gene ID: 11504, updated on 27-Jun-2015
    Official Symbol
    Adamts1provided by MGI
    Official Full Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1provided by MGI
    Primary source
    MGI:MGI:109249
    See related
    Ensembl:ENSMUSG00000022893; Vega:OTTMUSG00000019935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1; ADAMTS-1
    Orthologs
    See Adamts1 in Epigenomics, MapViewer
    Location:
    16 48.2 cM; 16 C3-C5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (85793827..85803115, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (85794072..85803360, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene RIKEN cDNA 4930556C24 gene Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    heart trabecula formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ovulation from ovarian follicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    proteinaceous extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 1
    Names
    A disintegrin and metalloproteinase with thrombospondin motifs 1
    ADAM-TS 1
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009621.4NP_033751.3  A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor

      See identical proteins and their annotated locations for NP_033751.3

      Status: VALIDATED

      Source sequence(s)
      BB619128, BC050834, BP764139, BY317513, D67076
      Consensus CDS
      CCDS28287.1
      UniProtKB/Swiss-Prot
      P97857
      Related
      ENSMUSP00000023610, OTTMUSP00000021492, ENSMUST00000023610, OTTMUST00000047513
      Conserved Domains (6) summary
      smart00209
      Location:563615
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:259464
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:259468
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:62174
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:726843
      ADAM_spacer1; ADAM-TS Spacer 1
      cl15456
      Location:469549
      ADAM_CR; ADAM cysteine-rich

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

      Range
      85793827..85803115
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000038.1 Alternate Mm_Celera

      Range
      86012366..86021639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)