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    AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 [ Homo sapiens (human) ]

    Gene ID: 10554, updated on 26-Jun-2015
    Official Symbol
    AGPAT1provided by HGNC
    Official Full Name
    1-acylglycerol-3-phosphate O-acyltransferase 1provided by HGNC
    Primary source
    HGNC:HGNC:324
    See related
    Ensembl:ENSG00000204310; HPRD:04372; MIM:603099; Vega:OTTHUMG00000031210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G15; LPAATA; 1-AGPAT1; LPAAT-alpha
    Summary
    This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
    Orthologs
    See AGPAT1 in Epigenomics, MapViewer
    Location:
    6p21.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (32168206..32178111, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (32135983..32145888, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene proline-rich transmembrane protein 1 Neighboring gene uncharacterized LOC100507547 Neighboring gene PPT2-EGFL8 readthrough (NMD candidate) Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene EGF-like-domain, multiple 8 Neighboring gene microRNA 6721 Neighboring gene microRNA 6833 Neighboring gene ring finger protein 5, E3 ubiquitin protein ligase Neighboring gene advanced glycosylation end product-specific receptor

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
    NHGRI GWA Catalog
    Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
    NHGRI GWA Catalog
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    NHGRI GWA Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    NHGRI GWA Catalog
    Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC4007, MGC5423

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    1-acylglycerol-3-phosphate O-acyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
    Names
    1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
    1-AGP acyltransferase 1
    1-AGPAT 1
    1-acylglycerol-3-phosphate O-acyltransferase 1 (acetoacetly Coenzyme A thiolase)
    1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
    lysophosphatidic acid acyltransferase alpha
    lysophospholipid acyltransferase
    NP_006402.1
    NP_116130.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006411.3NP_006402.1  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

      See identical proteins and their annotated locations for NP_006402.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI193422, BC004310, DA529681
      Consensus CDS
      CCDS4744.1
      UniProtKB/TrEMBL
      A0A024RCV5
      UniProtKB/Swiss-Prot
      Q99943
      Related
      ENSP00000364248, OTTHUMP00000029301, ENST00000375107, OTTHUMT00000076424
      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    2. NM_032741.4NP_116130.2  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

      See identical proteins and their annotated locations for NP_116130.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI193422, BC002402, BM763275, DB118884
      Consensus CDS
      CCDS4744.1
      UniProtKB/TrEMBL
      A0A024RCV5
      UniProtKB/Swiss-Prot
      Q99943
      Related
      ENSP00000337463, OTTHUMP00000029302, ENST00000336984, OTTHUMT00000076425
      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

      Range
      32168206..32178111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514234.1XP_011512536.1  

      See identical proteins and their annotated locations for XP_011512536.1

      Related
      ENSP00000378875, OTTHUMP00000029298, ENST00000395497, OTTHUMT00000076420
      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    2. XM_005248806.1XP_005248863.1  

      See identical proteins and their annotated locations for XP_005248863.1

      UniProtKB/TrEMBL
      A0A024RCV5
      UniProtKB/Swiss-Prot
      Q99943
      Related
      ENSP00000364245, OTTHUMP00000029299, ENST00000375104, OTTHUMT00000076421
      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    3. XM_005248805.2XP_005248862.1  

      See identical proteins and their annotated locations for XP_005248862.1

      Related
      ENSP00000378877, OTTHUMP00000174886, ENST00000395499, OTTHUMT00000268941
      Conserved Domains (1) summary
      cd07989
      Location:73259
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    Reference GRCh38.p2 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p2 ALT_REF_LOCI_1

      Range
      3500808..3510713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011546281.1XP_011544583.1  

      See identical proteins and their annotated locations for XP_011544583.1

      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    2. XM_005274830.1XP_005274887.1  

      See identical proteins and their annotated locations for XP_005274887.1

      UniProtKB/TrEMBL
      A0A024RCV5
      UniProtKB/Swiss-Prot
      Q99943
      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    3. XM_005274829.2XP_005274886.1  

      See identical proteins and their annotated locations for XP_005274886.1

      Conserved Domains (1) summary
      cd07989
      Location:73259
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    Reference GRCh38.p2 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p2 ALT_REF_LOCI_2

      Range
      3606558..3616463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011547171.1XP_011545473.1  

      See identical proteins and their annotated locations for XP_011545473.1

      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    2. XM_005272762.1XP_005272819.1  

      See identical proteins and their annotated locations for XP_005272819.1

      UniProtKB/TrEMBL
      A0A024RCV5
      UniProtKB/Swiss-Prot
      Q99943
      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    3. XM_005272761.2XP_005272818.1  

      See identical proteins and their annotated locations for XP_005272818.1

      Conserved Domains (1) summary
      cd07989
      Location:73259
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    Reference GRCh38.p2 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p2 ALT_REF_LOCI_4

      Range
      3473187..3483092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011547825.1XP_011546127.1  

      See identical proteins and their annotated locations for XP_011546127.1

      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    2. XM_005275074.1XP_005275131.1  

      See identical proteins and their annotated locations for XP_005275131.1

      UniProtKB/TrEMBL
      A0A024RCV5
      UniProtKB/Swiss-Prot
      Q99943
      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    3. XM_005275073.2XP_005275130.1  

      See identical proteins and their annotated locations for XP_005275130.1

      Conserved Domains (1) summary
      cd07989
      Location:73259
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    Reference GRCh38.p2 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p2 ALT_REF_LOCI_5

      Range
      3510227..3520132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011548005.1XP_011546307.1  

      See identical proteins and their annotated locations for XP_011546307.1

      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    2. XM_005275204.1XP_005275261.1  

      See identical proteins and their annotated locations for XP_005275261.1

      UniProtKB/TrEMBL
      A0A024RCV5
      UniProtKB/Swiss-Prot
      Q99943
      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    3. XM_005275203.2XP_005275260.1  

      See identical proteins and their annotated locations for XP_005275260.1

      Conserved Domains (1) summary
      cd07989
      Location:73259
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    Reference GRCh38.p2 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p2 ALT_REF_LOCI_6

      Range
      3391407..3401312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011548182.1XP_011546484.1  

      See identical proteins and their annotated locations for XP_011546484.1

      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    2. XM_005275338.1XP_005275395.1  

      See identical proteins and their annotated locations for XP_005275395.1

      UniProtKB/TrEMBL
      A0A024RCV5
      UniProtKB/Swiss-Prot
      Q99943
      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    3. XM_005275337.2XP_005275394.1  

      See identical proteins and their annotated locations for XP_005275394.1

      Conserved Domains (1) summary
      cd07989
      Location:73259
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    Reference GRCh38.p2 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p2 ALT_REF_LOCI_7

      Range
      3484413..3494318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011548377.1XP_011546679.1  

      See identical proteins and their annotated locations for XP_011546679.1

      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    2. XM_005275505.1XP_005275562.1  

      See identical proteins and their annotated locations for XP_005275562.1

      UniProtKB/TrEMBL
      A0A024RCV5
      UniProtKB/Swiss-Prot
      Q99943
      Conserved Domains (1) summary
      cd07989
      Location:69255
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    3. XM_005275504.2XP_005275561.1  

      See identical proteins and their annotated locations for XP_005275561.1

      Conserved Domains (1) summary
      cd07989
      Location:73259
      LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      32138467..32148372
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)