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    HDAC6 histone deacetylase 6 [ Homo sapiens (human) ]

    Gene ID: 10013, updated on 30-Jun-2015
    Official Symbol
    HDAC6provided by HGNC
    Official Full Name
    histone deacetylase 6provided by HGNC
    Primary source
    HGNC:HGNC:14064
    See related
    Ensembl:ENSG00000094631; HPRD:02228; MIM:300272; Vega:OTTHUMG00000034496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HD6; JM21; CPBHM; PPP1R90
    Summary
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
    Orthologs
    See HDAC6 in Epigenomics, MapViewer
    Location:
    Xp11.23
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (48801896..48824976)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48660086..48683408)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene acetyl-CoA acyltransferase 2 pseudogene Neighboring gene GATA binding protein 1 (globin transcription factor 1) Neighboring gene ES cell expressed Ras Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The binding of HIV-1 gp120 to CD4+-permissive cells increases the level of acetylated alpha-tubulin in a CD4-dependent manner; overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and prevents HIV-1-cell fusion PubMed
    Envelope transmembrane glycoprotein gp41 env Overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and remarkably prevents HIV-1 gp120/41-dependent cell fusion PubMed
    Tat tat HIV-1 Tat and HDAC6 interact in the cytoplasm in a microtubule-dependent manner, which leads to deacetylate Tat at position Lys28 and to inhibit Tat-mediated transactivation PubMed

    Go to the HIV-1, Human Interaction Database

    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Assembly of the primary cilium, organism-specific biosystem (from REACTOME)
      Assembly of the primary cilium, organism-specific biosystemThe primary cilium is one of two main types of cilia present on the surface of many eukaryotic cells (reviewed in Flieghauf et al, 2007). Unlike the motile cilia, which are generally present in large...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
    • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
      Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, organism-specific biosystemWhen found in cis, HD and PEST domain mutations act synergistically, increasing NOTCH1 transcriptional activity up to ~40-fold, compared with up to ~10-fold and up to ~2-fold increase with HD mutatio...
    • Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystem (from REACTOME)
      Constitutive Signaling by NOTCH1 PEST Domain Mutants, organism-specific biosystemAs NOTCH1 PEST domain is intracellular, NOTCH1 PEST domain mutants are expected to behave as the wild-type NOTCH1 with respect to ligand binding and proteolytic cleavage mediated activation of signal...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
      Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
    • HSF1 activation, organism-specific biosystem (from REACTOME)
      HSF1 activation, organism-specific biosystemHeat shock factor 1 (HSF1) is a transcription factor that activates gene expression in response to a variety of stresses, including heat shock, oxidative stress, as well as inflammation and infection...
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • Neural Crest Differentiation, organism-specific biosystem (from WikiPathways)
      Neural Crest Differentiation, organism-specific biosystemGene regulatory network model of cranial neural crest cell (CNCC) development, adaped from PMID: 19575671. Most interactions in the model are proposed to regulate transcription of core factors involv...
    • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
      Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer, organism-specific biosystemMutations in the heterodimerization domain (HD) and PEST domain of NOTCH1 are frequently found in cis in T-cell acute lymphoblastic leukemia. While HD mutations alone result in up to ~10-fold increas...
    • Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 PEST Domain Mutants in Cancer, organism-specific biosystemNOTCH1 PEST domain mutations are frequently found in T-cell acute lymphoblastic leukemia (T-ALL). PEST domain mutations interfere with ubiquitination-mediated NOTCH1 downregulation and result in prol...
    • Signaling by NOTCH1 in Cancer, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1 in Cancer, organism-specific biosystemHuman NOTCH1 was cloned as a chromosome 9 gene, translocated to the T-cell beta receptor (TCBR) promoter on chromosome 7 in T-cell acute lymphoblastic leukemia (T-ALL) (Ellisen et al. 1991). This tra...
    • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class I, organism-specific biosystem
      Signaling events mediated by HDAC Class I
    • Signaling events mediated by HDAC Class II, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by HDAC Class II, organism-specific biosystem
      Signaling events mediated by HDAC Class II
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ16239

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Hsp90 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    misfolded protein binding EXP
    Inferred from Experiment
    more info
     
    polyubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tau protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tubulin deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tubulin deacetylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Hsp90 deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of mitophagy in response to mitochondrial depolarization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    aggresome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to heat TAS
    Traceable Author Statement
    more info
     
    cellular response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to misfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to topologically incorrect protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H3 deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lysosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    misfolded or incompletely synthesized protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion localization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of hydrogen peroxide metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of microtubule depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of oxidoreductase activity IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of protein complex disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    organelle organization TAS
    Traceable Author Statement
    more info
     
    peptidyl-lysine deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    polyubiquitinated misfolded protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chaperone-mediated protein complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hydrogen peroxide-mediated programmed cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of receptor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein complex disassembly IEA
    Inferred from Electronic Annotation
    more info
     
    protein deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of androgen receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of establishment of protein localization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gene expression, epigenetic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of microtubule-based movement IC
    Inferred by Curator
    more info
    PubMed 
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to growth factor IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to misfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to organic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tubulin deacetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    aggresome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytoplasmic microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    histone deacetylase 6
    Names
    protein phosphatase 1, regulatory subunit 90
    NP_006035.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012560.1 RefSeqGene

      Range
      5001..27894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006044.2NP_006035.2  histone deacetylase 6

      See identical proteins and their annotated locations for NP_006035.2

      Status: REVIEWED

      Source sequence(s)
      AJ011972
      Consensus CDS
      CCDS14306.1
      UniProtKB/TrEMBL
      A0A024QZ26
      UniProtKB/Swiss-Prot
      Q9UBN7
      Related
      ENSP00000334061, OTTHUMP00000032398, ENST00000334136, OTTHUMT00000083394
      Conserved Domains (4) summary
      pfam09595
      Location:8911048
      Metaviral_G; Metaviral_G glycoprotein
      cd10003
      Location:485835
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:99435
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam02148
      Location:11331195
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

      Range
      48801896..48824976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272564.2XP_005272621.2  

      See identical proteins and their annotated locations for XP_005272621.2

      UniProtKB/TrEMBL
      B4DZH6
      Conserved Domains (4) summary
      pfam09595
      Location:9051062
      Metaviral_G; Metaviral_G glycoprotein
      cd10003
      Location:499849
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:113449
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam02148
      Location:11471209
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    2. XM_006724525.1XP_006724588.1  

      See identical proteins and their annotated locations for XP_006724588.1

      UniProtKB/TrEMBL
      A0A024QZ26
      UniProtKB/Swiss-Prot
      Q9UBN7
      Conserved Domains (4) summary
      pfam09595
      Location:8911048
      Metaviral_G; Metaviral_G glycoprotein
      cd10003
      Location:485835
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:99435
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam02148
      Location:11331195
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    3. XM_005272565.1XP_005272622.1  

      See identical proteins and their annotated locations for XP_005272622.1

      UniProtKB/TrEMBL
      A0A024QZ26
      UniProtKB/Swiss-Prot
      Q9UBN7
      Conserved Domains (4) summary
      pfam09595
      Location:8911048
      Metaviral_G; Metaviral_G glycoprotein
      cd10003
      Location:485835
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:99435
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam02148
      Location:11331195
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    4. XM_005272566.2XP_005272623.1  

      See identical proteins and their annotated locations for XP_005272623.1

      UniProtKB/TrEMBL
      A0A024QZ26
      UniProtKB/Swiss-Prot
      Q9UBN7
      Conserved Domains (4) summary
      pfam09595
      Location:8911048
      Metaviral_G; Metaviral_G glycoprotein
      cd10003
      Location:485835
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:99435
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam02148
      Location:11331195
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    5. XM_005272568.1XP_005272625.1  

      See identical proteins and their annotated locations for XP_005272625.1

      UniProtKB/TrEMBL
      A0A024QZ26
      UniProtKB/Swiss-Prot
      Q9UBN7
      Conserved Domains (4) summary
      pfam09595
      Location:8911048
      Metaviral_G; Metaviral_G glycoprotein
      cd10003
      Location:485835
      HDAC6-dom2; Histone deacetylase 6, domain 2
      cd11682
      Location:99435
      HDAC6-dom1; Histone deacetylase 6, domain 1
      pfam02148
      Location:11331195
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RNA

    1. XR_246712.2 RNA Sequence

    2. XR_949014.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      48691631..48714524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)