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    OR3A3 olfactory receptor family 3 subfamily A member 3 [ Homo sapiens (human) ]

    Gene ID: 8392, updated on 5-Mar-2024

    Summary

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    Official Symbol
    OR3A3provided by HGNC
    Official Full Name
    olfactory receptor family 3 subfamily A member 3provided by HGNC
    Primary source
    HGNC:HGNC:8284
    See related
    Ensembl:ENSG00000159961 AllianceGenome:HGNC:8284
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR3A6; OR3A7; OR3A8P; OR17-16; OR17-137; OR17-201
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    Location:
    17p13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (3411370..3424070)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (3300315..3312995)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (3314664..3327364)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 3 subfamily A member 2 Neighboring gene olfactory receptor family 1 subfamily R member 1 pseudogene Neighboring gene olfactory receptor family 1 subfamily E member 1 Neighboring gene olfactory receptor family 1 subfamily E member 2 Neighboring gene spermatogenesis associated 22 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:3386038-3386583 Neighboring gene aspartoacylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Population differences in the human functional olfactory repertoire. Gilad Y, et al. Mol Biol Evol, 2003 Mar. PMID 12644552
    2. Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. Ben-Arie N, et al. Hum Mol Genet, 1994 Feb. PMID 8004088
    3. Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. Glusman G, et al. Genomics, 2000 Jan 15. PMID 10673334
    4. Distribution of olfactory receptor genes in the human genome. Rouquier S, et al. Nat Genet, 1998 Mar. PMID 9500546
    5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Zody MC, et al. Nature, 2006 Apr 20. PMID 16625196, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 3A3
    Names
    olfactory receptor 17-201
    olfactory receptor 3A6
    olfactory receptor 3A7
    olfactory receptor 3A8
    olfactory receptor OR17-22
    olfactory receptor, family 3, subfamily A, member 6
    olfactory receptor, family 3, subfamily A, member 7
    olfactory receptor, family 3, subfamily A, member 8 pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386098.1 → NP_001373027.1  olfactory receptor 3A3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC025125
      Consensus CDS
      CCDS11025.2
      UniProtKB/Swiss-Prot
      P47888, Q2VPE4, Q6IFM6, Q9P1Q4, Q9UBE7
      UniProtKB/TrEMBL
      A0A126GWB3
      Related
      ENSP00000493211.1, ENST00000574571.4
      Conserved Domains (1) summary
      cd15233
      Location:28 → 304
      7tmA_OR3A-like; olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_012373.3 → NP_036505.3  olfactory receptor 3A3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC025125, AC087498
      Consensus CDS
      CCDS11025.2
      UniProtKB/Swiss-Prot
      P47888, Q2VPE4, Q6IFM6, Q9P1Q4, Q9UBE7
      UniProtKB/TrEMBL
      A0A126GWB3
      Related
      ENSP00000493061.1, ENST00000641141.1
      Conserved Domains (1) summary
      cd15233
      Location:28 → 304
      7tmA_OR3A-like; olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      3411370..3424070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      3300315..3312995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47888.3 GenPept UniProtKB/Swiss-Prot:P47888

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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