U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Crtc2 CREB regulated transcription coactivator 2 [ Mus musculus (house mouse) ]

    Gene ID: 74343, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Crtc2provided by MGI
    Official Full Name
    CREB regulated transcription coactivator 2provided by MGI
    Primary source
    MGI:MGI:1921593
    See related
    Ensembl:ENSMUSG00000027936 AllianceGenome:MGI:1921593
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Torc2; 4632407F12Rik
    Summary
    Predicted to enable cAMP response element binding protein binding activity and chromatin binding activity. Involved in gluconeogenesis; glucose homeostasis; and positive regulation of CREB transcription factor activity. Acts upstream of or within histone H3-K9 acetylation; positive regulation of transcription by RNA polymerase II; and toxin transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; ear; integumental system; limb; and nervous system. Orthologous to human CRTC2 (CREB regulated transcription coactivator 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 33.2), thymus adult (RPKM 31.7) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    3 F1; 3 39.21 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90161475..90171432)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90253858..90264125)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cAMP responsive element binding protein 3-like 4 Neighboring gene jumping translocation breakpoint Neighboring gene STARR-positive B cell enhancer ABC_E1265 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90052523-90052632 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:90057967-90058076 Neighboring gene solute carrier family 39 (zinc transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E4558 Neighboring gene DENN domain containing 4B Neighboring gene microRNA 7012 Neighboring gene STARR-positive B cell enhancer ABC_E28 Neighboring gene GATA zinc finger domain containing 2B Neighboring gene STARR-seq mESC enhancer starr_08281

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading. Gao L, et al. Arch Biochem Biophys, 2023 Jul 1. PMID 37164247
    2. A novel role of CRTC2 in promoting nonalcoholic fatty liver disease. Han HS, et al. Mol Metab, 2022 Jan. PMID 34838715, Free PMC Article
    3. CREB Coactivator CRTC2 Plays a Crucial Role in Endothelial Function. Kanki H, et al. J Neurosci, 2020 Dec 2. PMID 33127851, Free PMC Article
    4. CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers. Van de Velde S, et al. Mol Cell Biol, 2019 Sep 1. PMID 31182641, Free PMC Article
    5. A novel role for CRTC2 in hepatic cholesterol synthesis through SREBP-2. Li Y, et al. Hepatology, 2017 Aug. PMID 28395113, Free PMC Article

    See all (80) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRTC2 activates the epithelial-mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway.
      Title: CRTC2 activates the epithelial-mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway.
    2. Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress.
      Title: Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress.
    3. Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading.
      Title: Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading.
    4. cAMP-Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.
      Title: cAMP-Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.
    5. Endoplasmic reticulum stress downregulates PGC-1alpha in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2.
      Title: Endoplasmic reticulum stress downregulates PGC-1α in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2.
    6. IL-1beta-activated mTORC2 promotes accumulation of IFN-gamma(+) gammadelta T cells by upregulating CXCR3 to restrict hepatic fibrosis.
      Title: IL-1β-activated mTORC2 promotes accumulation of IFN-γ(+) γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis.
    7. A novel role of CRTC2 in promoting nonalcoholic fatty liver disease.
      Title: A novel role of CRTC2 in promoting nonalcoholic fatty liver disease.
    8. Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice.
      Title: Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice.
    9. A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex.
      Title: A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex.
    10. Sam68 promotes hepatic gluconeogenesis via CRTC2.
      Title: Sam68 promotes hepatic gluconeogenesis via CRTC2.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (7)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP response element binding protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of CREB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of CREB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein homotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    CREB-regulated transcription coactivator 2
    Names
    TORC-2
    transducer of CREB protein 2
    transducer of regulated cAMP response element-binding protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357152.2 → NP_001344081.1  CREB-regulated transcription coactivator 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC119825
      UniProtKB/TrEMBL
      Q3TDX5, Q8R1U3
      Related
      ENSMUST00000136970.8
      Conserved Domains (2) summary
      pfam12885
      Location:1 → 138
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:435 → 512
      TORC_C; Transducer of regulated CREB activity, C terminus

    2. NM_028881.4 → NP_083157.1  CREB-regulated transcription coactivator 2 isoform 1

      See identical proteins and their annotated locations for NP_083157.1

      Status: VALIDATED

      Source sequence(s)
      AC119825
      Consensus CDS
      CCDS38501.1
      UniProtKB/Swiss-Prot
      Q3TA52, Q3U182, Q8BH09
      Related
      ENSMUSP00000029545.9, ENSMUST00000029545.15
      Conserved Domains (3) summary
      pfam12884
      Location:18 → 72
      TORC_N; Transducer of regulated CREB activity, N terminus
      pfam12885
      Location:168 → 317
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:614 → 691
      TORC_C; Transducer of regulated CREB activity, C terminus

    RNA

    1. NR_151631.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC119825

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      90161475..90171432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502153.1 → XP_006502216.1  CREB-regulated transcription coactivator 2 isoform X2

      Conserved Domains (3) summary
      pfam12884
      Location:18 → 72
      TORC_N; Transducer of regulated CREB activity, N-terminus
      pfam12885
      Location:168 → 317
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:526 → 603
      TORC_C; Transducer of regulated CREB activity, C-terminus

    2. XM_006502152.1 → XP_006502215.1  CREB-regulated transcription coactivator 2 isoform X1

      Conserved Domains (3) summary
      pfam12884
      Location:18 → 72
      TORC_N; Transducer of regulated CREB activity, N-terminus
      pfam12885
      Location:145 → 294
      TORC_M; Transducer of regulated CREB activity middle domain
      pfam12886
      Location:591 → 668
      TORC_C; Transducer of regulated CREB activity, C-terminus

    RNA

    1. XR_001783761.1 RNA Sequence

    2. XR_375593.1 RNA Sequence

      Related
      ENSMUST00000184882.2

    3. XR_004941409.1 RNA Sequence

    4. XR_001783762.1 RNA Sequence

      Related
      ENSMUST00000130002.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U182.2 GenPept UniProtKB/Swiss-Prot:Q3U182

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous