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    Gtf2e2 general transcription factor II E, polypeptide 2 (beta subunit) [ Mus musculus (house mouse) ]

    Gene ID: 68153, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Gtf2e2provided by MGI
    Official Full Name
    general transcription factor II E, polypeptide 2 (beta subunit)provided by MGI
    Primary source
    MGI:MGI:1915403
    See related
    Ensembl:ENSMUSG00000031585 AllianceGenome:MGI:1915403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    34kDa; C330006J08Rik
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in transcription initiation from RNA polymerase II promoter. Predicted to be located in cytosol and nuclear speck. Predicted to be part of transcription factor TFIID complex and transcription factor TFIIE complex. Is expressed in several structures, including alimentary system; blastocyst; central nervous system; genitourinary system; and liver lobe. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 3.8), placenta adult (RPKM 3.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gtf2e2 in Genome Data Viewer
    Location:
    8 A4; 8 20.79 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34221942..34267201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33731914..33777173)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene glutathione reductase Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene predicted gene, 40485 Neighboring gene RIKEN cDNA 1700104B16 gene Neighboring gene STARR-seq mESC enhancer starr_21117 Neighboring gene small integral membrane protein 18 Neighboring gene RNA binding protein gene with multiple splicing Neighboring gene STARR-seq mESC enhancer starr_21127 Neighboring gene VISTA enhancer mm70 Neighboring gene STARR-seq mESC enhancer starr_21144 Neighboring gene STARR-seq mESC enhancer starr_21145 Neighboring gene predicted gene, 51528 Neighboring gene STARR-seq mESC enhancer starr_21150 Neighboring gene STARR-positive B cell enhancer mm9_chr8:35078702-35079003 Neighboring gene predicted gene, 33588

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A murine ATFa-associated factor with transcriptional repressing activity. De Graeve F, et al. Oncogene, 2000 Mar 30. PMID 10777215
    2. Reverse engineering a mouse embryonic stem cell-specific transcriptional network reveals a new modulator of neuronal differentiation. De Cegli R, et al. Nucleic Acids Res, 2013 Jan. PMID 23180766, Free PMC Article
    3. TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Alpern D, et al. Elife, 2014 Sep 10. PMID 25209997, Free PMC Article
    4. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article
    5. Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Kamileri I, et al. Proc Natl Acad Sci U S A, 2012 Feb 21. PMID 22323595, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to TFIIH-class transcription factor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIE subunit 2
    Names
    TFIIE-beta
    general transcription factor II E, polypeptide 2 (beta subunit, 34kD)
    general transcription factor IIE, polypeptide 2 (beta subunit, 34kD)
    transcription initiation factor IIE subunit beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167921.1 → NP_001161393.1  general transcription factor IIE subunit 2

      See identical proteins and their annotated locations for NP_001161393.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK146803, AW538417, CX239577, DV042794
      Consensus CDS
      CCDS22236.1
      UniProtKB/Swiss-Prot
      Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
      UniProtKB/TrEMBL
      Q9CWC4
      Related
      ENSMUSP00000126284.2, ENSMUST00000170705.8
      Conserved Domains (2) summary
      cd07977
      Location:69 → 147
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:147 → 205
      TFA2_Winged_2; TFA2 Winged helix domain 2

    2. NM_001167922.1 → NP_001161394.1  general transcription factor IIE subunit 2

      See identical proteins and their annotated locations for NP_001161394.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK146803, AW538417, BX516160, DV042794
      Consensus CDS
      CCDS22236.1
      UniProtKB/Swiss-Prot
      Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
      UniProtKB/TrEMBL
      Q9CWC4
      Related
      ENSMUSP00000132287.2, ENSMUST00000171010.8
      Conserved Domains (2) summary
      cd07977
      Location:69 → 147
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:147 → 205
      TFA2_Winged_2; TFA2 Winged helix domain 2

    3. NM_026584.3 → NP_080860.3  general transcription factor IIE subunit 2

      See identical proteins and their annotated locations for NP_080860.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK146803, AW538417, BY256665, DV042794
      Consensus CDS
      CCDS22236.1
      UniProtKB/Swiss-Prot
      Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
      UniProtKB/TrEMBL
      Q9CWC4
      Related
      ENSMUSP00000129834.2, ENSMUST00000167264.8
      Conserved Domains (2) summary
      cd07977
      Location:69 → 147
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:147 → 205
      TFA2_Winged_2; TFA2 Winged helix domain 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      34221942..34267201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509188.4 → XP_006509251.1  general transcription factor IIE subunit 2 isoform X2

      See identical proteins and their annotated locations for XP_006509251.1

      UniProtKB/Swiss-Prot
      Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
      UniProtKB/TrEMBL
      Q9CWC4
      Conserved Domains (2) summary
      cd07977
      Location:69 → 147
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:147 → 205
      TFA2_Winged_2; TFA2 Winged helix domain 2

    2. XM_006509186.3 → XP_006509249.1  general transcription factor IIE subunit 2 isoform X2

      See identical proteins and their annotated locations for XP_006509249.1

      UniProtKB/Swiss-Prot
      Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
      UniProtKB/TrEMBL
      Q9CWC4
      Conserved Domains (2) summary
      cd07977
      Location:69 → 147
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:147 → 205
      TFA2_Winged_2; TFA2 Winged helix domain 2

    3. XM_006509187.2 → XP_006509250.1  general transcription factor IIE subunit 2 isoform X2

      See identical proteins and their annotated locations for XP_006509250.1

      UniProtKB/Swiss-Prot
      Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
      UniProtKB/TrEMBL
      Q9CWC4
      Conserved Domains (2) summary
      cd07977
      Location:69 → 147
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:147 → 205
      TFA2_Winged_2; TFA2 Winged helix domain 2

    4. XM_036154260.1 → XP_036010153.1  general transcription factor IIE subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
      UniProtKB/TrEMBL
      Q9CWC4
      Conserved Domains (2) summary
      cd07977
      Location:69 → 147
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:147 → 205
      TFA2_Winged_2; TFA2 Winged helix domain 2

    5. XM_036154258.1 → XP_036010151.1  general transcription factor IIE subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
      UniProtKB/TrEMBL
      Q9CWC4
      Conserved Domains (2) summary
      cd07977
      Location:69 → 147
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:147 → 205
      TFA2_Winged_2; TFA2 Winged helix domain 2

    6. XM_030243746.2 → XP_030099606.1  general transcription factor IIE subunit 2 isoform X2

      UniProtKB/Swiss-Prot
      Q3U5Y7, Q8BTZ2, Q8VE14, Q9D902
      UniProtKB/TrEMBL
      Q9CWC4
      Conserved Domains (2) summary
      cd07977
      Location:69 → 147
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:147 → 205
      TFA2_Winged_2; TFA2 Winged helix domain 2

    7. XM_006509185.5 → XP_006509248.1  general transcription factor IIE subunit 2 isoform X1

      UniProtKB/TrEMBL
      Q9CWC4
      Conserved Domains (2) summary
      cd07977
      Location:72 → 150
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:150 → 208
      TFA2_Winged_2; TFA2 Winged helix domain 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D902.2 GenPept UniProtKB/Swiss-Prot:Q9D902

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