Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnajc7provided by MGI
Official Full Name: DnaJ heat shock protein family (Hsp40) member C7provided by MGI
Primary source: MGI:MGI:1928373
See related: Ensembl:ENSMUSG00000014195 AllianceGenome:MGI:1928373
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CCRP; Ttc2; mDj11; mTpr2; 2010003F24Rik; 2010004G07Rik
Summary: Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 43.0), CNS E14 (RPKM 34.9) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.47 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100473644..100511030, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100582818..100620292, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation.
Title: DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation.
present study characterized a novel physiological role of CCRP in protecting cardiac functions through the inhibition of NFkappaB signaling.
Title: Co-Chaperone-Mediated Suppression of LPS-Induced Cardiac Toxicity Through NFκB Signaling.
In CCRP knockout (KO) mice CCRP regulates CAR at multiple steps in activation of the cytochrome 2b10 gene in liver: nuclear accumulation, RNA polymerase II recruitment and epigenetic modifications.
Title: The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers.
ubiquitin-proteasomal regulation of CCRP and HSP70 are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers
Title: Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system.
cytoplasmic constitutive active/androstane receptor retention protein mediates the retention of PXR in the cytosol and modulates the activation of PXR in response to Pregnenolone Carbonitrile treatment
Title: Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MDB0128 (e-PCR)
- UniSTS:125010

RH126706 (e-PCR)
- UniSTS:208745

RH125110 (e-PCR)
- UniSTS:161932

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dnaJ homolog subfamily C member 7

Names: DnaJ (Hsp40) homolog, subfamily C, member 7; TPR repeat protein 2; cytoplasmic CAR retention protein; tetratricopeptide repeat domain 2; tetratricopeptide repeat protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378962.1 → NP_001365891.1 dnaJ homolog subfamily C member 7 isoform 2

Status: VALIDATED

Source sequence(s)

AL591469, BX842667

UniProtKB/TrEMBL

A0A6I8MX00, A2A5E1

Related

ENSMUSP00000115438.3, ENSMUST00000146840.3

Conserved Domains (4) summary

PLN03088
Location:237 → 337

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

COG0484
Location:364 → 453

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

TIGR00990
Location:8 → 337

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:241 → 268

TPR; TPR repeat [structural motif]
NM_001378963.1 → NP_001365892.1 dnaJ homolog subfamily C member 7 isoform 3

Status: VALIDATED

Source sequence(s)

AL591469

UniProtKB/TrEMBL

A0A6I8MWW2, A0A6I8MX31

Related

ENSMUSP00000159367.2, ENSMUST00000154972.9

Conserved Domains (2) summary

TIGR00990
Location:19 → 136

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:28 → 56

TPR; TPR repeat [structural motif]
NM_001403603.1 → NP_001390532.1 dnaJ homolog subfamily C member 7 isoform 1

Status: VALIDATED

Source sequence(s)

AL591469, BX842667

UniProtKB/Swiss-Prot

Q3TKR1, Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026, Q9QYI3

Related

ENSMUSP00000159311.2, ENSMUST00000239410.2
NM_019795.5 → NP_062769.2 dnaJ homolog subfamily C member 7 isoform 1

See identical proteins and their annotated locations for NP_062769.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL591469, BX842667

Consensus CDS

CCDS25428.1

UniProtKB/Swiss-Prot

Q3TKR1, Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026, Q9QYI3

UniProtKB/TrEMBL

Q3UL32

Related

ENSMUSP00000014339.9, ENSMUST00000014339.15

Conserved Domains (7) summary

smart00028
Location:28 → 61

TPR; Tetratricopeptide repeats

COG0484
Location:380 → 469

DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

sd00006
Location:257 → 284

TPR; TPR repeat [structural motif]

pfam00226
Location:381 → 448

DnaJ; DnaJ domain

pfam00515
Location:294 → 327

TPR_1; Tetratricopeptide repeat

pfam13414
Location:27 → 92

TPR_11; TPR repeat

pfam13431
Location:50 → 82

TPR_17; Tetratricopeptide repeat

RNA

NR_166203.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL591469, BX842667

Related

ENSMUST00000239418.2
NR_166204.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL591469, BX842667

Related

ENSMUST00000239499.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

100473644..100511030 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156865.1 → XP_036012758.1 dnaJ homolog subfamily C member 7 isoform X2

Conserved Domains (2) summary

TIGR00990
Location:104 → 221

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:113 → 141

TPR; TPR repeat [structural motif]