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    FHL2 four and a half LIM domains 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 474544, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FHL2provided by VGNC
    Official Full Name
    four and a half LIM domains 2provided by VGNC
    Primary source
    VGNC:VGNC:40872
    See related
    Ensembl:ENSCAFG00845009612
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 10
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 10 NC_051814.1 (38854939..38922615)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 10 NC_006592.4 (37924199..37991867)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 10 NC_049231.1 (39050777..39118466)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 10 NC_049270.1 (38579623..38647260)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 10 NC_049751.1 (38859021..38926610)

    Chromosome 10 - NC_051814.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119873770 Neighboring gene uncharacterized LOC102155326 Neighboring gene uncharacterized LOC111097692 Neighboring gene uncharacterized LOC111097691 Neighboring gene U6 spliceosomal RNA Neighboring gene chromosome 10 C2orf49 homolog Neighboring gene uncharacterized LOC106559387 Neighboring gene transforming growth factor beta receptor associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    four and a half LIM domains protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051814.1 Reference ROS_Cfam_1.0

      Range
      38854939..38922615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038680169.1 → XP_038536097.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Related
      ENSCAFP00845013189.1, ENSCAFT00845016942.1
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_038680175.1 → XP_038536103.1  four and a half LIM domains protein 2 isoform X2

      Conserved Domains (2) summary
      cd09433
      Location:113 → 170
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:54 → 110
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_038680172.1 → XP_038536100.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_038680173.1 → XP_038536101.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    5. XM_038680171.1 → XP_038536099.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Related
      ENSCAFP00845013215.1, ENSCAFT00845016969.1
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    6. XM_038680170.1 → XP_038536098.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    7. XM_038680174.1 → XP_038536102.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049270.1 Alternate UMICH_Zoey_3.1

      Range
      38579623..38647260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038488917.1 → XP_038344845.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_038488924.1 → XP_038344852.1  four and a half LIM domains protein 2 isoform X2

      Conserved Domains (2) summary
      cd09433
      Location:113 → 170
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:54 → 110
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_038488921.1 → XP_038344849.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_038488922.1 → XP_038344850.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    5. XM_038488919.1 → XP_038344847.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    6. XM_038488918.1 → XP_038344846.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    7. XM_038488923.1 → XP_038344851.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049751.1 Alternate UNSW_CanFamBas_1.0

      Range
      38859021..38926610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038614797.1 → XP_038470725.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_038614803.1 → XP_038470731.1  four and a half LIM domains protein 2 isoform X2

      Conserved Domains (2) summary
      cd09433
      Location:113 → 170
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:54 → 110
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_038614799.1 → XP_038470727.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_038614800.1 → XP_038470728.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    5. XM_038614802.1 → XP_038470730.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    6. XM_038614798.1 → XP_038470726.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    7. XM_038614801.1 → XP_038470729.1  four and a half LIM domains protein 2 isoform X1

      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049231.1 Alternate UU_Cfam_GSD_1.0

      Range
      39050777..39118466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038550886.1 → XP_038406814.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_038550892.1 → XP_038406820.1  four and a half LIM domains protein 2 isoform X2

      Conserved Domains (2) summary
      cd09433
      Location:113 → 170
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:54 → 110
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_038550889.1 → XP_038406817.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_038550890.1 → XP_038406818.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    5. XM_038550888.1 → XP_038406816.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    6. XM_038550887.1 → XP_038406815.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    7. XM_038550891.1 → XP_038406819.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006592.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      37924199..37991867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_531773.7 → XP_531773.3  four and a half LIM domains protein 2 isoform X1

      See identical proteins and their annotated locations for XP_531773.3

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_038643656.1 → XP_038499584.1  four and a half LIM domains protein 2 isoform X2

      Conserved Domains (2) summary
      cd09433
      Location:113 → 170
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:54 → 110
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_005625988.4 → XP_005626045.1  four and a half LIM domains protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005626045.1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. XM_022424545.2 → XP_022280253.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    5. XM_005625987.4 → XP_005626044.1  four and a half LIM domains protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005626044.1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    6. XM_005625989.4 → XP_005626046.1  four and a half LIM domains protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005626046.1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    7. XM_038643648.1 → XP_038499576.1  four and a half LIM domains protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KBV8, A0A8C0PHY3, A0A8I3NCC4, A0A8I3NEJ6, A0A8P0S7Y2
      Conserved Domains (2) summary
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:101 → 157
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein
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