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    IL18 interleukin 18 [ Homo sapiens (human) ]

    Gene ID: 3606, updated on 28-Jun-2015
    Official Symbol
    IL18provided by HGNC
    Official Full Name
    interleukin 18provided by HGNC
    Primary source
    HGNC:HGNC:5986
    See related
    Ensembl:ENSG00000150782; HPRD:02976; MIM:600953; Vega:OTTHUMG00000167006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IGIF; IL-18; IL-1g; IL1F4
    Summary
    The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
    Orthologs
    See IL18 in Epigenomics, MapViewer
    Location:
    11q22.2-q22.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (112143251..112164117, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (112013974..112034840, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369495 Neighboring gene succinate dehydrogenase complex, subunit D, integral membrane protein Neighboring gene testis expressed 12 Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 4 Neighboring gene beta-carotene oxygenase 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    NHGRI GWA Catalog
    Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels.
    NHGRI GWA Catalog
    Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Both acute HIV-1 infection and incubation of the THP-1 monocytes with HIV-1 Nef downregulate IL-18 expression PubMed
    Tat tat HIV-1 Tat upregulates the expression of interleukin 18 gene (IL18) in mammary epithelial cells PubMed

    Go to the HIV-1, Human Interaction Database

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    • African trypanosomiasis, conserved biosystem (from KEGG)
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    • Cellular roles of Anthrax toxin, organism-specific biosystem (from Pathway Interaction Database)
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    • Corticotropin-releasing hormone, organism-specific biosystem (from WikiPathways)
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    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
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    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
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    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
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    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
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    • Hypertrophy Model, organism-specific biosystem (from WikiPathways)
      Hypertrophy Model, organism-specific biosystem
      Hypertrophy Model
    • IL12 signaling mediated by STAT4, organism-specific biosystem (from Pathway Interaction Database)
      IL12 signaling mediated by STAT4, organism-specific biosystem
      IL12 signaling mediated by STAT4
    • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL12-mediated signaling events, organism-specific biosystem
      IL12-mediated signaling events
    • IL23-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL23-mediated signaling events, organism-specific biosystem
      IL23-mediated signaling events
    • IL27-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      IL27-mediated signaling events, organism-specific biosystem
      IL27-mediated signaling events
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
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    • Influenza A, organism-specific biosystem (from KEGG)
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    • Influenza A, conserved biosystem (from KEGG)
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    • Interleukin-1 processing, organism-specific biosystem (from REACTOME)
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    • Legionellosis, organism-specific biosystem (from KEGG)
      Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
    • Legionellosis, conserved biosystem (from KEGG)
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    • Malaria, organism-specific biosystem (from KEGG)
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    • NOD pathway, organism-specific biosystem (from WikiPathways)
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    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
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    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
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    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
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    • Salmonella infection, organism-specific biosystem (from KEGG)
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    • Tuberculosis, organism-specific biosystem (from KEGG)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC12320

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T-helper 1 type immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to organic cyclic compound IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemokine biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    granulocyte macrophage colony-stimulating factor biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interferon-gamma biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-13 biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    interleukin-2 biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    natural killer cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NK T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of activated T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of granulocyte macrophage colony-stimulating factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of inflammatory response IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-17 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of natural killer cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tissue remodeling IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of Stat3 protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sleep ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    type 2 immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    interleukin-18
    Names
    interleukin-18
    IFN-gamma-inducing factor
    IL-1 gamma
    iboctadekin
    interleukin 18 (interferon-gamma-inducing factor)
    interleukin-1 gamma

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028143.1 RefSeqGene

      Range
      5001..25867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243211.1NP_001230140.1  interleukin-18 isoform 2 proprotein

      See identical proteins and their annotated locations for NP_001230140.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2) missing a 4 aa peptide compared to isoform 1.
      Source sequence(s)
      AY266351, BC007461, BU633686
      Consensus CDS
      CCDS58180.1
      UniProtKB/TrEMBL
      A0A024R3E0
      UniProtKB/Swiss-Prot
      Q14116
      Related
      ENSP00000434561, OTTHUMP00000234750, ENST00000524595, OTTHUMT00000392410
      Conserved Domains (1) summary
      pfam00340
      Location:68181
      IL1; Interleukin-1 / 18
    2. NM_001562.3NP_001553.1  interleukin-18 isoform 1 proprotein

      See identical proteins and their annotated locations for NP_001553.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1).
      Source sequence(s)
      AY266351, BC007461, BU633686, D49950
      Consensus CDS
      CCDS44731.1
      UniProtKB/Swiss-Prot
      Q14116
      Related
      ENSP00000280357, OTTHUMP00000234749, ENST00000280357, OTTHUMT00000392409
      Conserved Domains (1) summary
      pfam00340
      Location:72185
      IL1; Interleukin-1 / 18

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

      Range
      112143251..112164117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542806.1XP_011541108.1  

      See identical proteins and their annotated locations for XP_011541108.1

      Conserved Domains (1) summary
      pfam00340
      Location:72185
      IL1; Interleukin-1 / 18
    2. XM_011542805.1XP_011541107.1  

      See identical proteins and their annotated locations for XP_011541107.1

      Conserved Domains (1) summary
      pfam00340
      Location:68181
      IL1; Interleukin-1 / 18

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      111897441..111918303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)