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    HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [ Homo sapiens (human) ]

    Gene ID: 3363, updated on 28-Jun-2015
    Official Symbol
    HTR7provided by HGNC
    Official Full Name
    5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupledprovided by HGNC
    Primary source
    HGNC:HGNC:5302
    See related
    Ensembl:ENSG00000148680; HPRD:01639; MIM:182137; Vega:OTTHUMG00000018732
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5-HT7
    Summary
    The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
    Orthologs
    See HTR7 in Epigenomics, MapViewer
    Location:
    10q21-q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (90740818..90857914, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (92500575..92617671, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378426 Neighboring gene uncharacterized LOC101926942 Neighboring gene ribonuclease P/MRP 30kDa subunit Neighboring gene ankyrin repeat domain 1 (cardiac muscle)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common genetic variants and gene expression associated with white matter microstructure in the human brain.
    NHGRI GWA Catalog
    • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • GPCRs, Other, organism-specific biosystem (from WikiPathways)
      GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
      Monoamine GPCRs, organism-specific biosystem
      Monoamine GPCRs
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Serotonergic synapse, organism-specific biosystem (from KEGG)
      Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
    • Serotonin Receptor 4/6/7 and NR3C Signaling, organism-specific biosystem (from WikiPathways)
      Serotonin Receptor 4/6/7 and NR3C Signaling, organism-specific biosystemThis pathway is courtesy of Ariadne Genomics Pathway Studio.
    • Serotonin receptors, organism-specific biosystem (from REACTOME)
      Serotonin receptors, organism-specific biosystemSerotonin (5-HT) is a monoamine neurotransmitter that plays an important role as a modulator of anger, aggression, body temperature, mood, sleep, sexuality, appetite, metabolism, as well as stimulati...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
    Traceable Author Statement
    more info
    PubMed 
    blood circulation TAS
    Traceable Author Statement
    more info
    PubMed 
    circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    serotonin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    5-hydroxytryptamine receptor 7
    Names
    5-hydroxytryptamine receptor 7
    5-HT-7
    5-HT-X
    5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029218.1 RefSeqGene

      Range
      5001..122097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000872.4NP_000863.1  5-hydroxytryptamine receptor 7 isoform a

      See identical proteins and their annotated locations for NP_000863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) results from the alternative usage of the first of two tandemly arranged splice donor sites at the 5' end of intron 2, which causes the protein to have a 13 amino acid longer carboxy tail relative to isoform b.
      Source sequence(s)
      BC047526, BG108256
      Consensus CDS
      CCDS7409.1
      UniProtKB/Swiss-Prot
      P34969
      Related
      ENSP00000277874, OTTHUMP00000020078, ENST00000277874, OTTHUMT00000049344
      Conserved Domains (2) summary
      pfam00001
      Location:106384
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10320
      Location:98215
      7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx
    2. NM_019859.3NP_062873.1  5-hydroxytryptamine receptor 7 isoform d

      See identical proteins and their annotated locations for NP_062873.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) results from the inclusion of a 98 base pair exon cassette (exon D) at the exon II/exon III boundary, as compared to splice variant a. The inclusion of exon D results in a protein with a carboxy terminal end 34 amino acids longer than the splice variant a protein.
      Source sequence(s)
      BC047526, BG108256, U68488
      Consensus CDS
      CCDS7408.1
      UniProtKB/Swiss-Prot
      P34969
      Related
      ENSP00000337949, OTTHUMP00000020077, ENST00000336152, OTTHUMT00000049343
      Conserved Domains (2) summary
      pfam00001
      Location:106384
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam10320
      Location:98215
      7TM_GPCR_Srsx; Serpentine type 7TM GPCR chemoreceptor Srsx
    3. NM_019860.3NP_062874.1  5-hydroxytryptamine receptor 7 isoform b

      See identical proteins and their annotated locations for NP_062874.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) results from the alternative usage of the second of the two tandemly arranged splice donor sites at the 5' end of intron 2, which causes an in-frame stop codon and shortens the protein's carboxy tail by 13 amino acids relative to isoform a.
      Source sequence(s)
      BC047526, BG108256, U68487
      Consensus CDS
      CCDS7410.1
      UniProtKB/Swiss-Prot
      P34969
      Related
      ENSP00000360784, OTTHUMP00000020079, ENST00000371719, OTTHUMT00000049345
      Conserved Domains (2) summary
      pfam00001
      Location:106384
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:98215
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

      Range
      90740818..90857914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      92778457..92895518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)