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    Tuba4a tubulin, alpha 4A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316531, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tuba4aprovided by RGD
    Official Full Name
    tubulin, alpha 4Aprovided by RGD
    Primary source
    RGD:1359623
    See related
    Ensembl:ENSRNOG00000003597 AllianceGenome:RGD:1359623
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tuba4
    Summary
    Predicted to enable GTP binding activity and protein kinase binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 22. Orthologous to human TUBA4A (tubulin alpha 4a). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 1136.6), Heart (RPKM 991.9) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9q33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84158871..84174041, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76709617..76714327, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82415599..82419918, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 Neighboring gene galactosidase, beta 1-like Neighboring gene serine/threonine kinase 16 Neighboring gene uncharacterized LOC102554903 Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene uncharacterized LOC120094712 Neighboring gene protein tyrosine phosphatase, receptor type, N

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A revised nomenclature for the human and rodent alpha-tubulin gene family. Khodiyar VK, et al. Genomics, 2007 Aug. PMID 17543498
    2. Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. Saito TT, et al. PLoS Genet, 2013. PMID 23874210, Free PMC Article
    3. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. Villasante A, et al. Mol Cell Biol, 1986 Jul. PMID 3785200, Free PMC Article
    4. Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Kaczmarski W, et al. J Neurosci Res, 2014 Feb. PMID 24327345, Free PMC Article
    5. PEX14 is required for microtubule-based peroxisome motility in human cells. Bharti P, et al. J Cell Sci, 2011 May 15. PMID 21525035

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94628

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin alpha-4A chain
    Names
    alpha-tubulin 4
    tubulin alpha-4 chain
    tubulin, alpha 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007004.2 → NP_001007005.1  tubulin alpha-4A chain

      See identical proteins and their annotated locations for NP_001007005.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q5XIF6
      UniProtKB/TrEMBL
      A0A8I6ALV8, A6JVZ9
      Related
      ENSRNOP00000004797.5, ENSRNOT00000004797.6
      Conserved Domains (1) summary
      PTZ00335
      Location:1 → 448
      PTZ00335; tubulin alpha chain; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      84158871..84174041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267230.1 → XP_063123300.1  tubulin alpha-4A chain isoform X1

      UniProtKB/Swiss-Prot
      Q5XIF6
      UniProtKB/TrEMBL
      A6JVZ9

    2. XM_006245227.4 → XP_006245289.1  tubulin alpha-4A chain isoform X2

      See identical proteins and their annotated locations for XP_006245289.1

      UniProtKB/TrEMBL
      A0A8I6ALV8
      Conserved Domains (1) summary
      PTZ00335
      Location:1 → 433
      PTZ00335; tubulin alpha chain; Provisional

    3. XM_063267231.1 → XP_063123301.1  tubulin alpha-4A chain isoform X2

    4. XM_039083681.2 → XP_038939609.1  tubulin alpha-4A chain isoform X2

      UniProtKB/TrEMBL
      A0A8I6ALV8
      Conserved Domains (1) summary
      PTZ00335
      Location:1 → 433
      PTZ00335; tubulin alpha chain; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIF6.1 GenPept UniProtKB/Swiss-Prot:Q5XIF6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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