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    Hsph1 heat shock protein family H (Hsp110) member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288444, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Hsph1provided by RGD
    Official Full Name
    heat shock protein family H (Hsp110) member 1provided by RGD
    Primary source
    RGD:1311609
    See related
    Ensembl:ENSRNOG00000000902 AllianceGenome:RGD:1311609
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hsp105
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity and alpha-tubulin binding activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within several processes, including chaperone cofactor-dependent protein refolding; negative regulation of intracellular signal transduction; and positive regulation of nitrogen compound metabolic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Predicted to colocalize with microtubule. Orthologous to human HSPH1 (heat shock protein family H (Hsp110) member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 213.3), Kidney (RPKM 139.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    12p11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (10427368..10446602)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (5390916..5410224)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (6322685..6341898, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene beta 3-glucosyltransferase Neighboring gene small nucleolar RNA SNORA67 Neighboring gene uncharacterized LOC108352411 Neighboring gene WD40 repeat domain 95 Neighboring gene uncharacterized LOC120095877

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased expression of heat shock protein 105 in rat uterus of early pregnancy and its significance in embryo implantation. Yuan JX, et al. Reprod Biol Endocrinol, 2009 Mar 13. PMID 19284651, Free PMC Article
    2. Nuclear localization mechanism of Hsp105beta and its possible function in mammalian cells. Saito Y, et al. J Biochem, 2009 Feb. PMID 19028714
    3. Mammalian 105 kDa heat shock family proteins suppress hydrogen peroxide-induced apoptosis through a p38 MAPK-dependent mitochondrial pathway in HeLa cells. Yamagishi N, et al. FEBS J, 2008 Sep. PMID 18681888
    4. Different localization of Hsp105 family proteins in mammalian cells. Saito Y, et al. Exp Cell Res, 2007 Oct 15. PMID 17643418
    5. Hsp105 family proteins suppress staurosporine-induced apoptosis by inhibiting the translocation of Bax to mitochondria in HeLa cells. Yamagishi N, et al. Exp Cell Res, 2006 Oct 15. PMID 16857185

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Temporal and spatial changes in Hsp105 expression in pregnant rat uterus has a physiological role in regulating embryo implantation.
      Title: Increased expression of heat shock protein 105 in rat uterus of early pregnancy and its significance in embryo implantation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of establishment of protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heat shock protein 105 kDa
    Names
    heat shock 105/110 protein 1
    heat shock 105kDa
    heat shock 105kDa/110kDa protein 1
    heat shock 110 kDa protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011901.2 → NP_001011901.1  heat shock protein 105 kDa

      See identical proteins and their annotated locations for NP_001011901.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      Q66HA8
      UniProtKB/TrEMBL
      A0A8I6GLC4, A6K161
      Related
      ENSRNOP00000001201.6, ENSRNOT00000001201.8
      Conserved Domains (1) summary
      cd11739
      Location:2 → 384
      HSPH1_NBD; Nucleotide-binding domain of HSPH1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      10427368..10446602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089153.2 → XP_038945081.1  heat shock protein 105 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXF4, A0A8I6GLC4
      Related
      ENSRNOP00000082622.1
      Conserved Domains (1) summary
      cd11739
      Location:2 → 384
      HSPH1_NBD; Nucleotide-binding domain of HSPH1

    2. XM_063271115.1 → XP_063127185.1  heat shock protein 105 kDa isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HA8.1 GenPept UniProtKB/Swiss-Prot:Q66HA8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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