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    Mvk mevalonate kinase [ Mus musculus (house mouse) ]

    Gene ID: 17855, updated on 26-Jun-2015
    Official Symbol
    Mvkprovided by MGI
    Official Full Name
    mevalonate kinaseprovided by MGI
    Primary source
    MGI:MGI:107624
    See related
    Ensembl:ENSMUSG00000041939; Vega:OTTMUSG00000014479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MK; AI256848; AI414037; 2310010A05Rik
    Summary
    This gene encodes mevalonate kinase, a key enzyme involved in the biosynthesis of cholesterol and non-sterol isoprenes. The complete lack of encoded protein is lethal to mouse embryos. Mice lacking one allele of this gene exhibit increased levels of mevalonate in spleen, heart and kidney, as well as increased levels of serum immunoglobulins A and D. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
    Orthologs
    Location:
    5 F; 5 55.99 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (114444257..114460591)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (114894315..114910600)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ubiquitin protein ligase E3B Neighboring gene microRNA 7027 Neighboring gene methylmalonic aciduria (cobalamin deficiency) type B homolog (human) Neighboring gene predicted gene, 34722 Neighboring gene predicted gene 13790

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    mevalonate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mevalonate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    isopentenyl diphosphate biosynthetic process, mevalonate pathway ISO
    Inferred from Sequence Orthology
    more info
     
    isoprenoid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    mevalonate kinase
    Names
    mevalonate kinase
    NP_076045.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306205.1NP_001293134.1  mevalonate kinase isoform 1

      See identical proteins and their annotated locations for NP_001293134.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132102, AI849730, AK149630
    2. NM_023556.3NP_076045.1  mevalonate kinase isoform 2

      See identical proteins and their annotated locations for NP_076045.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC132102, AI849730, AK149630
      Consensus CDS
      CCDS19566.1
      UniProtKB/Swiss-Prot
      Q9R008
      Related
      ENSMUSP00000036971, OTTMUSP00000015400, ENSMUST00000043760, OTTMUST00000034379
      Conserved Domains (2) summary
      PLN02677
      Location:10377
      PLN02677; mevalonate kinase
      pfam00288
      Location:130212
      GHMP_kinases_N; GHMP kinases N terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

      Range
      114444257..114460591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530184.1XP_006530247.1  

      Related
      ENSMUSP00000107858, OTTMUSP00000015401, ENSMUST00000112239, OTTMUST00000034383
      Conserved Domains (2) summary
      PLN02677
      Location:10389
      PLN02677; mevalonate kinase
      pfam00288
      Location:142224
      GHMP_kinases_N; GHMP kinases N terminal domain
    2. XM_006530183.1XP_006530246.1  

      See identical proteins and their annotated locations for XP_006530246.1

      UniProtKB/TrEMBL
      Q3UEB4
      Conserved Domains (2) summary
      PLN02677
      Location:10389
      PLN02677; mevalonate kinase
      pfam00288
      Location:142224
      GHMP_kinases_N; GHMP kinases N terminal domain
    3. XM_006530185.2XP_006530248.1  

      See identical proteins and their annotated locations for XP_006530248.1

      UniProtKB/Swiss-Prot
      Q9R008
      Conserved Domains (2) summary
      PLN02677
      Location:10377
      PLN02677; mevalonate kinase
      pfam00288
      Location:130212
      GHMP_kinases_N; GHMP kinases N terminal domain

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      111543727..111559933
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)