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    TMEM106A transmembrane protein 106A [ Homo sapiens (human) ]

    Gene ID: 113277, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TMEM106Aprovided by HGNC
    Official Full Name
    transmembrane protein 106Aprovided by HGNC
    Primary source
    HGNC:HGNC:28288
    See related
    Ensembl:ENSG00000184988 AllianceGenome:HGNC:28288
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be involved in several processes, including glycoprotein biosynthetic process; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney (RPKM 9.2), appendix (RPKM 4.7) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    17q21.31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43211875..43220041)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44070653..44078810)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41363894..41372061)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene BRCA1 DNA repair associated Neighboring gene uncharacterized LOC101929767 Neighboring gene uncharacterized LOC124900391 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12237 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12239 Neighboring gene BRCA1 pseudogene 1 Neighboring gene NBR1 autophagy cargo receptor Neighboring gene Sharpr-MPRA regulatory region 10579 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41379300-41379489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41381411-41382085 Neighboring gene coiled-coil domain containing 200 Neighboring gene RNA, U2 small nuclear 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TMEM106A inhibits enveloped virus release from cell surface. Mao D, et al. iScience, 2022 Feb 18. PMID 35198896, Free PMC Article
    2. Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis. Xu D, et al. J Cell Mol Med, 2014 Aug. PMID 24975047, Free PMC Article
    3. Transmembrane protein 106a activates mouse peritoneal macrophages via the MAPK and NF-κB signaling pathways. Dai H, et al. Sci Rep, 2015 Jul 28. PMID 26215746, Free PMC Article
    4. A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. Garcia-Casado Z, et al. BMC Med Genet, 2011 Oct 11. PMID 21989022, Free PMC Article
    5. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. Dart AE, et al. J Cell Biol, 2015 Nov 23. PMID 26598620, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Low TMEM106A expression is associated with gastric cancer.
      Title: Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ50420, FLJ50717, FLJ77644, MGC20235, MGC182077, MGC182126

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CD80 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in CD86 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of MHC class II biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interleukin-1 beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of nitric oxide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 106A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291586.2 → NP_001278515.1  transmembrane protein 106A isoform a

      See identical proteins and their annotated locations for NP_001278515.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
      Source sequence(s)
      AC024051, AK290387, BQ013276
      Consensus CDS
      CCDS11462.1
      UniProtKB/Swiss-Prot
      A8K2X2, B7Z698, Q96A25
      UniProtKB/TrEMBL
      K7ERE2
      Related
      ENSP00000466820.1, ENST00000588659.5
      Conserved Domains (1) summary
      pfam07092
      Location:25 → 252
      DUF1356; Protein of unknown function (DUF1356)

    2. NM_001291587.2 → NP_001278516.1  transmembrane protein 106A isoform b

      See identical proteins and their annotated locations for NP_001278516.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame segment in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AC024051, AK299974, BQ013276
      Consensus CDS
      CCDS74073.1
      UniProtKB/Swiss-Prot
      Q96A25
      Related
      ENSP00000439844.1, ENST00000541594.5
      Conserved Domains (1) summary
      pfam07092
      Location:2 → 204
      DUF1356; Protein of unknown function (DUF1356)

    3. NM_001291588.2 → NP_001278517.1  transmembrane protein 106A isoform c

      See identical proteins and their annotated locations for NP_001278517.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AC024051, AK301571, BQ013276
      Consensus CDS
      CCDS77039.1
      UniProtKB/TrEMBL
      B7Z779, K7ERE2
      Related
      ENSP00000439835.1, ENST00000536052.5
      Conserved Domains (1) summary
      pfam07092
      Location:25 → 205
      DUF1356; Protein of unknown function (DUF1356)

    4. NM_145041.4 → NP_659478.1  transmembrane protein 106A isoform a

      See identical proteins and their annotated locations for NP_659478.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC024051, AK056132, BQ013276
      Consensus CDS
      CCDS11462.1
      UniProtKB/Swiss-Prot
      A8K2X2, B7Z698, Q96A25
      UniProtKB/TrEMBL
      K7ERE2
      Related
      ENSP00000483246.1, ENST00000612339.4
      Conserved Domains (1) summary
      pfam07092
      Location:25 → 252
      DUF1356; Protein of unknown function (DUF1356)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43211875..43220041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      44070653..44078810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96A25.1 GenPept UniProtKB/Swiss-Prot:Q96A25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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