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    Psph phosphoserine phosphatase [ Mus musculus (house mouse) ]

    Gene ID: 100678, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Psphprovided by MGI
    Official Full Name
    phosphoserine phosphataseprovided by MGI
    Primary source
    MGI:MGI:97788
    See related
    Ensembl:ENSMUSG00000029446 AllianceGenome:MGI:97788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSP; PSPase
    Summary
    Predicted to enable L-phosphoserine phosphatase activity; magnesium ion binding activity; and protein homodimerization activity. Acts upstream of or within in utero embryonic development. Predicted to be located in neuron projection. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; integumental system; liver; and urinary system. Human ortholog(s) of this gene implicated in PSPH deficiency. Orthologous to human PSPH (phosphoserine phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 14.8), liver E14 (RPKM 8.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G1.3; 5 68.26 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129842622..129864318, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129765558..129787443, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11303 Neighboring gene mitochondrial ribosomal protein S17 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:130230774-130230883 Neighboring gene nipsnap homolog 2 Neighboring gene STARR-seq mESC enhancer starr_14458 Neighboring gene STARR-seq mESC enhancer starr_14459 Neighboring gene STARR-positive B cell enhancer ABC_E854 Neighboring gene predicted gene, 23245 Neighboring gene chaperonin containing TCP1 subunit 6A Neighboring gene small nucleolar RNA, H/ACA box 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Meehan TF, et al. Nat Genet, 2017 Aug. PMID 28650483, Free PMC Article
    2. Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Nakano I, et al. Stem Cells, 2007 Aug. PMID 17495110
    3. ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH. Wang T, et al. Mol Ther, 2023 Mar 1. PMID 36639869, Free PMC Article
    4. L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis. Bachelor MA, et al. J Dermatol Sci, 2011 Sep. PMID 21726982, Free PMC Article
    5. Chromosomal and regional localization of the loci for IGKC, IGGC, ALDB, HOXB, GPT, and PRNP in the American mink (Mustela vison): comparisons with human and mouse. Khlebodarova TM, et al. Mamm Genome, 1995 Oct. PMID 8563168

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH.
      Title: ABRO1 arrests cardiomyocyte proliferation and myocardial repair by suppressing PSPH.
    2. status of PSPH in normal skin epidermis and skin tumors along with its sub-cellular localization in epidermal keratinocytes and its requirement for squamous cell carcinoma proliferation
      Title: L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis.
    3. PSP has a role in neural stem cell proliferation and may regulate signaling between neural stem cells and other cells within the stem cell niche.
      Title: Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-phosphoserine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-phosphoserine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-serine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-serine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-serine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphoserine phosphatase
    Names
    O-phosphoserine phosphohydrolase
    NP_598661.1
    XP_006504337.1
    XP_006504338.1
    XP_017176063.1
    XP_030109871.1
    XP_030109872.1
    XP_030109873.1
    XP_036020582.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133900.4 → NP_598661.1  phosphoserine phosphatase

      See identical proteins and their annotated locations for NP_598661.1

      Status: VALIDATED

      Source sequence(s)
      AA003039, AI841354, BQ177662, BY125431, BY127546, CV560928
      Consensus CDS
      CCDS19699.1
      UniProtKB/Swiss-Prot
      Q3TI16, Q5XHW3, Q99LS3
      Related
      ENSMUSP00000031399.7, ENSMUST00000031399.13
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      129842622..129864318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504274.5 → XP_006504337.1  phosphoserine phosphatase isoform X1

      See identical proteins and their annotated locations for XP_006504337.1

      UniProtKB/Swiss-Prot
      Q3TI16, Q5XHW3, Q99LS3
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    2. XM_030254011.1 → XP_030109871.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      Q3TI16, Q5XHW3, Q99LS3
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    3. XM_036164689.1 → XP_036020582.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      Q3TI16, Q5XHW3, Q99LS3
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    4. XM_030254012.2 → XP_030109872.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      Q3TI16, Q5XHW3, Q99LS3
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    5. XM_030254013.2 → XP_030109873.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      Q3TI16, Q5XHW3, Q99LS3
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    6. XM_017320574.1 → XP_017176063.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      Q3TI16, Q5XHW3, Q99LS3
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    7. XM_006504275.4 → XP_006504338.1  phosphoserine phosphatase isoform X2

      Conserved Domains (1) summary
      cd04309
      Location:1 → 165
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LS3.1 GenPept UniProtKB/Swiss-Prot:Q99LS3

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