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piwi [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34521, updated on 22-Jul-2014
Official Symbol
piwiprovided by FlyBase
Primary source
FLYBASE:FBgn0004872
Locus tag
Dmel_CG6122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6122; Dmel\CG6122; Piwi; PIWI
See piwi in Epigenomics, MapViewer
Location:
32C1-32C1
Exon count:
8
Annotation release Status Assembly Chr Location
Build 5.57 current Release 5 (GCF_000001215.2) 2L NT_033779.4 (10982205..10987420, complement)

Chromosome 2L - NT_033779.4Genomic Context describing neighboring genes Neighboring gene lethal (2) 06225 Neighboring gene abnormal oocyte Neighboring gene CG4636 gene product from transcript CG4636-RD Neighboring gene CG12253 gene product from transcript CG12253-RA Neighboring gene CG16833 gene product from transcript CG16833-RM Neighboring gene aubergine

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

mobile_element

  • Loc: c10984863-10984721 mobile_element_type = transposon:Cr1a{}6251

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding NAS
Non-traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA interference TAS
Traceable Author Statement
more info
PubMed 
cell fate determination TAS
Traceable Author Statement
more info
PubMed 
chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
female germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
PubMed 
gene silencing by RNA IMP
Inferred from Mutant Phenotype
more info
 
germ-line stem cell division TAS
Traceable Author Statement
more info
PubMed 
germ-line stem cell maintenance IDA
Inferred from Direct Assay
more info
PubMed 
germ-line stem cell maintenance TAS
Traceable Author Statement
more info
PubMed 
heterochromatin organization involved in chromatin silencing IMP
Inferred from Mutant Phenotype
more info
 
male germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transposition IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of transposition, DNA-mediated IMP
Inferred from Mutant Phenotype
more info
PubMed 
pole cell formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
 
posttranscriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Yb body IPI
Inferred from Physical Interaction
more info
 
chromatin IDA
Inferred from Direct Assay
more info
 
chromocenter IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasm NAS
Non-traceable Author Statement
more info
 
euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
polytene chromosome IDA
Inferred from Direct Assay
more info
PubMed 
telomeric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
CG6122 gene product from transcript CG6122-RA
Names
CG6122-PA
CG6122-PB
P-element induced wimpy testis
piwi
piwi-PA
piwi-PB

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.4 

    Range
    10982205..10987420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057527.4NP_476875.1  piwi, isoform A [Drosophila melanogaster]

    See proteins identical to NP_476875.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VKM1
    UniProtKB/TrEMBL
    X2J7U0
    Related
    FBpp0079755
    Conserved Domains (2) summary
    cd02845
    Location:254374
    Blast Score: 428
    PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
    cd04658
    Location:382826
    Blast Score: 1463
    Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...
  2. NM_001298896.1NP_001285825.1  piwi, isoform B [Drosophila melanogaster]

    See proteins identical to NP_001285825.1

    Status: REVIEWED