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    VPS21 Rab family GTPase VPS21 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854256, updated on 23-Aug-2016
    Gene symbol
    VPS21
    Gene description
    Rab family GTPase VPS21
    Primary source
    SGD:S000005615
    Locus tag
    YOR089C
    Gene type
    protein coding
    RNA name
    Rab family GTPase VPS21
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VPS12; VPT12; YPT21; YPT51
    See VPS21 in Map Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (490196..490828, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene Yvc1p Neighboring gene type 2C protein phosphatase PTC5 Neighboring gene Tma46p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Phagosome, organism-specific biosystem (from KEGG)
      Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    • Phagosome, conserved biosystem (from KEGG)
      Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Golgi to endosome transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Golgi to endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    late endosome to vacuole transport via multivesicular body sorting pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multivesicular body assembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to endosome IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    reticulophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    vacuole inheritance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Names
    Rab family GTPase VPS21
    NP_014732.1
    • Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      490196..490828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183508.1NP_014732.1  Rab family GTPase VPS21 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_014732.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P36017
      Conserved Domains (2) summary
      cd01860
      Location:7172
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
      pfam00071
      Location:9172
      Ras; Ras family