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    Kl Klotho [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83504, updated on 26-Apr-2016
    Official Symbol
    Klprovided by RGD
    Official Full Name
    Klothoprovided by RGD
    Primary source
    RGD:620396
    See related
    Ensembl:ENSRNOG00000001092
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Summary
    may be involved in suprresion of aging phenotypes [RGD, Feb 2006]
    Orthologs
    Location:
    12p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (942974..987206)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (929158..972144)

    Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548832 Neighboring gene uncharacterized LOC102548900 Neighboring gene uncharacterized LOC102548964 Neighboring gene StAR-related lipid transfer domain containing 13

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    beta-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    beta-glucuronidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    fibroblast growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acute inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    aging ISO
    Inferred from Sequence Orthology
    more info
     
    aging TAS
    Traceable Author Statement
    more info
    PubMed 
    calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    energy reserve metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    energy reserve metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glycosyl compound metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    norepinephrine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of bone mineralization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to angiotensin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to fibroblast growth factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to vitamin D IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031336.1NP_112626.1  klotho precursor

      See identical proteins and their annotated locations for NP_112626.1

      Status: PROVISIONAL

      Source sequence(s)
      AB017820
      UniProtKB/Swiss-Prot
      Q9Z2Y9
      Related
      ENSRNOP00000001449, ENSRNOT00000001449
      Conserved Domains (3) summary
      COG2723
      Location:584954
      BglB; Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism]
      pfam00232
      Location:59508
      Glyco_hydro_1; Glycosyl hydrolase family 1
      cl01046
      Location:64499
      BglB; Beta-glucosidase/6-phospho-beta-glucosidase/beta-galactosidase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

      Range
      942974..987206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000080.1 Alternate Rn_Celera

      Range
      2195730..2234485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)