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IFNL4 interferon, lambda 4 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 101180976, updated on 9-Nov-2014
Official Symbol
IFNL4provided by HGNC
Official Full Name
interferon, lambda 4 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:44480
See related
Ensembl:ENSG00000272395; MIM:615090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IFNAN
See IFNL4 in Epigenomics, MapViewer
Location:
19q13.2
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (39246314..39248856, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39736954..39739496, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene interferon, lambda 3 pseudogene 1 Neighboring gene interferon, lambda 3 Neighboring gene methionine sulfoxide reductase B1 pseudogene 1 Neighboring gene interferon, lambda 4 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.
NHGRI GWA Catalog
Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts.
NHGRI GWA Catalog

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of immune response IEA
Inferred from Electronic Annotation
more info
 
tyrosine phosphorylation of Stat1 protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
tyrosine phosphorylation of Stat2 protein IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
interferon lambda-4
Names
interferon lambda-4
IFN-lambda-4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276254.2NP_001263183.2  interferon lambda-4 precursor

    See proteins identical to NP_001263183.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents a protein coding transcript of this gene. Human populations are polymorphic for a frameshifting single nucleotide insertion in this transcript and thus transcripts with the alternate allele are non-coding.
    Source sequence(s)
    JN806234
    UniProtKB/Swiss-Prot
    K9M1U5
    Conserved Domains (1) summary
    pfam15177
    Location:25173
    IL28A; Interleukin-28A

RNA

  1. NR_074079.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, non-coding) has a single frameshifting nucleotide insertion, compared to variant 1, which renders this transcript subject to nonsense-mediated mRNA decay (NMD). Human populations are polymorphic for a frameshifting single nucleotide insertion in this transcript and thus transcripts with the alternate allele are protein coding. The non-coding allele is represented in GRCh38.
    Source sequence(s)
    JN806227
    Related
    ENST00000610963

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    36183999..36186540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    39246314..39248856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    39737763..39740305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)