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    Ager advanced glycosylation end product-specific receptor [ Mus musculus (house mouse) ]

    Gene ID: 11596, updated on 1-Feb-2016
    Official Symbol
    Agerprovided by MGI
    Official Full Name
    advanced glycosylation end product-specific receptorprovided by MGI
    Primary source
    MGI:MGI:893592
    See related
    Ensembl:ENSMUSG00000015452; Vega:OTTMUSG00000037074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RAGE
    Orthologs
    See Ager in Epigenomics, MapViewer
    Location:
    17; 17 B1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (34597410..34600937)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34734807..34737877)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene G-protein signalling modulator 3 (AGS3-like, C. elegans) Neighboring gene pre B cell leukemia homeobox 2 Neighboring gene ring finger protein 5 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) Neighboring gene EGF-like domain 8

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    S100 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    advanced glycation end-product binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    advanced glycation end-product receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    high mobility group box 1 binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    induction of positive chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of advanced glycation end-product receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of advanced glycation end-product receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of collagen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of connective tissue replacement involved in inflammatory response wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of signaling ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of advanced glycation end-product receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-12 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of monocyte chemotactic protein-1 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of potassium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of CD4-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of T cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    advanced glycosylation end product-specific receptor
    Names
    advanced glycation end-products receptor
    receptor for advanced glycation end-products variant 20
    receptor for advanced glycosylation end products

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271422.1NP_001258351.1  advanced glycosylation end product-specific receptor isoform b precursor

      See identical proteins and their annotated locations for NP_001258351.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AK004802, CT009767
      Consensus CDS
      CCDS70795.1
      UniProtKB/TrEMBL
      C5H3H7
      Related
      ENSMUSP00000134401, OTTMUSP00000053231, ENSMUST00000174496, OTTMUST00000095385
      Conserved Domains (4) summary
      cd00096
      Location:253305
      Ig; Immunoglobulin domain
      smart00408
      Location:249304
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:24116
      IG_like; Immunoglobulin like
      pfam08205
      Location:123216
      C2-set_2; CD80-like C2-set immunoglobulin domain
    2. NM_001271423.1NP_001258352.1  advanced glycosylation end product-specific receptor isoform c precursor

      See identical proteins and their annotated locations for NP_001258352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an in-frame exon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      CT009767
      Consensus CDS
      CCDS70796.1
      UniProtKB/TrEMBL
      C5H7W9
      Related
      ENSMUSP00000134579, OTTMUSP00000053232, ENSMUST00000173992, OTTMUST00000095386
      Conserved Domains (4) summary
      cd00096
      Location:244296
      Ig; Immunoglobulin domain
      smart00408
      Location:240295
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:24107
      IG_like; Immunoglobulin like
      pfam08205
      Location:114207
      C2-set_2; CD80-like C2-set immunoglobulin domain
    3. NM_001271424.1NP_001258353.1  advanced glycosylation end product-specific receptor isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains multiple differences in the coding region, compared to variant 1, and initiates translation at an alternate start codon. The encodes isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      CT009767
      Conserved Domains (3) summary
      cd00096
      Location:170222
      Ig; Immunoglobulin domain
      smart00408
      Location:166221
      IGc2; Immunoglobulin C-2 Type
      pfam08205
      Location:40133
      C2-set_2; CD80-like C2-set immunoglobulin domain
    4. NM_007425.3NP_031451.2  advanced glycosylation end product-specific receptor isoform a precursor

      See identical proteins and their annotated locations for NP_031451.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC061182, CT009767
      Consensus CDS
      CCDS28649.1
      UniProtKB/TrEMBL
      O35444
      Related
      ENSMUSP00000015596, OTTMUSP00000053230, ENSMUST00000015596, OTTMUST00000095384
      Conserved Domains (4) summary
      cd00096
      Location:253305
      Ig; Immunoglobulin domain
      smart00408
      Location:249304
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:24116
      IG_like; Immunoglobulin like
      pfam08205
      Location:123216
      C2-set_2; CD80-like C2-set immunoglobulin domain

    RNA

    1. NR_073173.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate splicing structure near the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CT009767
      Related
      ENSMUST00000174069, OTTMUST00000095396
    2. NR_073175.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has an alternate splicing structure near the 5' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CT009767
      Related
      ENSMUST00000172932
    3. NR_073176.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has an alternate splicing structure near the 5' end, and lacks an exon near the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CT009767

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

      Range
      34597410..34600937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523501.2XP_006523564.1  

      See identical proteins and their annotated locations for XP_006523564.1

      Conserved Domains (5) summary
      cd00096
      Location:34110
      Ig; Immunoglobulin domain
      smart00408
      Location:249277
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:24116
      IG_like; Immunoglobulin like
      pfam08205
      Location:123216
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:240277
      Ig_2; Immunoglobulin domain

    Reference GRCm38.p3 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p3 129X1/SvJ

      Range
      846179..849706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525275.2XP_006525338.1  

      See identical proteins and their annotated locations for XP_006525338.1

      Conserved Domains (5) summary
      cd00096
      Location:34110
      Ig; Immunoglobulin domain
      smart00408
      Location:249277
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:24116
      IG_like; Immunoglobulin like
      pfam08205
      Location:123216
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:240277
      Ig_2; Immunoglobulin domain

    Reference GRCm38.p3 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p3 NOD/MrkTac

      Range
      917059..920506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537233.2XP_006537296.1  

      See identical proteins and their annotated locations for XP_006537296.1

      Conserved Domains (5) summary
      cd00096
      Location:34110
      Ig; Immunoglobulin domain
      smart00408
      Location:249277
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:24116
      IG_like; Immunoglobulin like
      pfam08205
      Location:123216
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:240277
      Ig_2; Immunoglobulin domain

    Reference GRCm38.p3 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p3 NOD/ShiLtJ

      Range
      917309..920756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536500.2XP_006536563.1  

      See identical proteins and their annotated locations for XP_006536563.1

      Conserved Domains (5) summary
      cd00096
      Location:34110
      Ig; Immunoglobulin domain
      smart00408
      Location:249277
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:24116
      IG_like; Immunoglobulin like
      pfam08205
      Location:123216
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:240277
      Ig_2; Immunoglobulin domain

    Alternate Mm_Celera

    Genomic

    1. AC_000039.1 Alternate Mm_Celera

      Range
      37693010..37696097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)