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    NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) [ Homo sapiens (human) ]

    Gene ID: 2908, updated on 30-Jun-2015
    Official Symbol
    NR3C1provided by HGNC
    Official Full Name
    nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)provided by HGNC
    Primary source
    HGNC:HGNC:7978
    See related
    Ensembl:ENSG00000113580; HPRD:00679; MIM:138040; Vega:OTTHUMG00000129677
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GR; GCR; GRL; GCCR; GCRST
    Summary
    This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
    Orthologs
    See NR3C1 in Epigenomics, MapViewer
    Location:
    5q31.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (143277931..143435512, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (142657496..143113322, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene ARHGAP26 antisense RNA 1 Neighboring gene ARHGAP26 intronic transcript 1 Neighboring gene uncharacterized LOC105378206 Neighboring gene ribosomal protein L7 pseudogene 21 Neighboring gene uncharacterized LOC105378207 Neighboring gene uncharacterized LOC105378208

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Glucocorticoid resistance, generalized
    MedGen: CN205763 OMIM: 615962 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies new susceptibility loci for migraine.
    NHGRI GWA Catalog
    Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr Glucocorticoid receptor (GR) agonists, dexamethasone (Dex) and medroxyprogesterone acetate (MPA), enhance HIV-1 Vpr peptide (amino acids 52-96)-mediated apoptosis of CD4+ T-cells in a GR-dependent manner PubMed
    vpr HIV-1 Vpr leucine residues mediate Vpr-Glucocorticoid Receptor (GR) interaction and promoter transactivation; mutation at residue L22 results in 8- to 11-fold higher GRE and HIV-1 LTR transactivation, while L42 and L67 mutants showed reduced activation PubMed
    vpr HIV-1 Vpr activates transcription of glucocorticoid-responsive promoters by binding directly to p300/CBP co-activators, forming a stable complex with p300 and interacting with ligand-bound glucocorticoid receptor PubMed
    vpr HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on NF-kappa B and activating protein 1-regulated simple promoters PubMed
    vpr HIV-1 Vpr (amino acids 22-26 and 64-68) binds to and activates glucocorticoid receptor (GR) and transactivates the HIV-1 LTR promoter through the host GR pathway PubMed
    vpr HIV-1 Vpr targets the glucocorticoid receptor type II complex through an interaction with Vpr interacting protein 1 (Rip-1), a 41 kDa cytosolic protein that binds to Vpr and in a complex with the human glucocorticoid receptor PubMed
    vpr HIV-1 Vpr affects the gene expression of glucocorticoid-regulated genes (IL-12, CD44, Toll-like receptor 4 and indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1) through activation of the GR pathway PubMed
    vpr Studies suggest effects of HIV-1 Vpr on cytokine expression (IL-2, IL-10, IL-12, TNFalpha and IL-4) and T-cell proliferation may be mediated through activation of the glucocorticoid receptor pathway PubMed
    vpr Interaction of HIV-1 Vpr and hVIP/mov34 may be involved in the activation of glucocorticoid receptor by Vpr PubMed
    vpr Transcription factors TFIIH, CDK7, Cyclin H, and MAT1 enhance HIV-1 Vpr activation of glucocorticoid receptor PubMed
    vpr HIV-1 Vpr synergistically enhances SRC-1 ligand-activated glucocorticoid receptor activity PubMed
    vpr HIV-1 Vpr (amino acids 1-35) binds to TFIID, an interaction that is associated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway PubMed
    vpr Specific binding of HIV-1 Vpr (amino acids 15-35) to TFIIB (amino acids 52-55) causes a conformational change in TFIIB and is correlated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    adrenal gland development IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to steroid hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    gene expression TAS
    Traceable Author Statement
    more info
     
    glucocorticoid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    glucocorticoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glucocorticoid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    maternal behavior IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of glucocorticoid mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of glucocorticoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    transcription, DNA-templated TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial matrix TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    glucocorticoid receptor
    Names
    glucocorticoid nuclear receptor variant 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009062.1 RefSeqGene

      Range
      5001..162582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000176.2NP_000167.1  glucocorticoid receptor isoform alpha

      See identical proteins and their annotated locations for NP_000167.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes the predominant physiological isoform (alpha, also known as GRalpha or GR-A). Variants 1-5 encode the same isoform.
      Source sequence(s)
      AC004782, AC091925, BX648553, X03225, X03348
      Consensus CDS
      CCDS4278.1
      UniProtKB/TrEMBL
      F1D8N4
      UniProtKB/Swiss-Prot
      P04150
      Related
      ENSP00000377977, OTTHUMP00000160085, ENST00000394464, OTTHUMT00000251880
      Conserved Domains (3) summary
      cd07076
      Location:531777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
    2. NM_001018074.1NP_001018084.1  glucocorticoid receptor isoform alpha

      See identical proteins and their annotated locations for NP_001018084.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
      Source sequence(s)
      AC004782, AC091925, X03225
      Consensus CDS
      CCDS4278.1
      UniProtKB/TrEMBL
      F1D8N4
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:531777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
    3. NM_001018075.1NP_001018085.1  glucocorticoid receptor isoform alpha

      See identical proteins and their annotated locations for NP_001018085.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha)
      Source sequence(s)
      AC004782, AC091925, X03225
      Consensus CDS
      CCDS4278.1
      UniProtKB/TrEMBL
      F1D8N4
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:531777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
    4. NM_001018076.1NP_001018086.1  glucocorticoid receptor isoform alpha

      See identical proteins and their annotated locations for NP_001018086.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
      Source sequence(s)
      AC004782, BF966114, X03225
      Consensus CDS
      CCDS4278.1
      UniProtKB/TrEMBL
      F1D8N4
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:531777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
    5. NM_001018077.1NP_001018087.1  glucocorticoid receptor isoform alpha

      See identical proteins and their annotated locations for NP_001018087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
      Source sequence(s)
      AC004782, AC091925, X03225
      Consensus CDS
      CCDS4278.1
      UniProtKB/TrEMBL
      F1D8N4
      UniProtKB/Swiss-Prot
      P04150
      Related
      ENSP00000343205, ENST00000343796
      Conserved Domains (3) summary
      cd07076
      Location:531777
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
    6. NM_001020825.1NP_001018661.1  glucocorticoid receptor isoform beta

      See identical proteins and their annotated locations for NP_001018661.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (beta, also known as GRbeta) with a distinct C-terminus compared to isoform alpha. This isoform resides primarily in the nucleus, lacks hormone-binding activity, and has a dominant negative effect on the action of isoform alpha (PMID:8621628).
      Source sequence(s)
      AC004782, AC091925, X03348
      Consensus CDS
      CCDS47298.1
      UniProtKB/TrEMBL
      E5KQF5
      UniProtKB/Swiss-Prot
      P04150
      Related
      ENSP00000387672, OTTHUMP00000222851, ENST00000415690, OTTHUMT00000370825
      Conserved Domains (3) summary
      cd07172
      Location:417494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
      cl11397
      Location:531729
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    7. NM_001024094.1NP_001019265.1  glucocorticoid receptor isoform gamma

      See identical proteins and their annotated locations for NP_001019265.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate in-frame donor splice site at one of the coding exons compared to variant 1. This results in an isoform (gamma) that is 1 aa longer than isoform alpha. The insertion of an additional amino acid (arginine) in the DNA binding domain has been reported to decrease transcriptional activation by the glucocorticoid receptor (PMID:10566686).
      Source sequence(s)
      AC004782, AC091925, U01351
      Consensus CDS
      CCDS34258.1
      UniProtKB/TrEMBL
      E5KQF6
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:532778
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417495
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
    8. NM_001204258.1NP_001191187.1  glucocorticoid receptor isoform alpha-B

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-B, also known as GR-B) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 571-573).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:505751
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:391468
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:1375
      GCR; Glucocorticoid receptor
    9. NM_001204259.1NP_001191188.1  glucocorticoid receptor isoform alpha-C1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C1, also known as GR-C1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 748-750).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:446692
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:332409
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:1316
      GCR; Glucocorticoid receptor
    10. NM_001204260.1NP_001191189.1  glucocorticoid receptor isoform alpha-C2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C2, also known as GR-C2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 760-762).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:442688
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:328405
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:1312
      GCR; Glucocorticoid receptor
    11. NM_001204261.1NP_001191190.1  glucocorticoid receptor isoform alpha-C3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternative in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C3, also known as GR-C3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 784-786).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:434680
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:320397
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:1304
      GCR; Glucocorticoid receptor
    12. NM_001204262.1NP_001191191.1  glucocorticoid receptor isoform alpha-D1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D1, also known as GR-D1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1438-1440).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:216462
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:102179
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:186
      GCR; Glucocorticoid receptor
    13. NM_001204263.1NP_001191192.1  glucocorticoid receptor isoform alpha-D2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D2, also known as GR-D2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1483-1485).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:201447
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:87164
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:171
      GCR; Glucocorticoid receptor
    14. NM_001204264.1NP_001191193.1  glucocorticoid receptor isoform alpha-D3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D3, also known as GR-D3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1498-1500).
      Source sequence(s)
      AC004782, AC091925, CA425706, U01351, X03225
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:196442
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:82159
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:166
      GCR; Glucocorticoid receptor
    15. NM_001204265.1NP_001191194.1  glucocorticoid receptor isoform GR-P

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as GR-P) is missing 2 exons from the 3' end, and has a different 3' end compared to variant 1. This results in an isoform (GR-P) with a shorter and unique C-terminus compared to isoform alpha. The function of the encoded protein is not known, however, this variant is highly expressed in cells that are resistant to glucocorticoids, and may act to modulate glucocorticoid responsiveness (PMIDs:7796394, 11358809).
      Source sequence(s)
      AA737284, AC091925, BF244382, U01351, U25029
      Conserved Domains (3) summary
      cd07172
      Location:417494
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
      cl11397
      Location:531674
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

      Range
      143277931..143435512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268422.2XP_005268479.1  

      See identical proteins and their annotated locations for XP_005268479.1

      UniProtKB/TrEMBL
      E5KQF6
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:532778
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417495
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
    2. XM_005268419.2XP_005268476.1  

      See identical proteins and their annotated locations for XP_005268476.1

      UniProtKB/TrEMBL
      E5KQF6
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:532778
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417495
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
    3. XM_005268423.2XP_005268480.1  

      See identical proteins and their annotated locations for XP_005268480.1

      UniProtKB/TrEMBL
      E5KQF6
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:532778
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417495
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
    4. XM_005268420.3XP_005268477.1  

      See identical proteins and their annotated locations for XP_005268477.1

      UniProtKB/TrEMBL
      E5KQF6
      UniProtKB/Swiss-Prot
      P04150
      Conserved Domains (3) summary
      cd07076
      Location:532778
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:417495
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam02155
      Location:26401
      GCR; Glucocorticoid receptor
    5. XM_011537637.1XP_011535939.1  

      See identical proteins and their annotated locations for XP_011535939.1

      Conserved Domains (2) summary
      cd07076
      Location:134380
      NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:2097
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    6. XM_011537636.1XP_011535938.1  

      Conserved Domains (1) summary
      pfam02155
      Location:26394
      GCR; Glucocorticoid receptor

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      142091205..142248804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)