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    NHP6A high-mobility group nucleosome-binding protein [ Saccharomyces cerevisiae S288c ]

    Gene ID: 856165, updated on 5-Jun-2016
    Gene symbol
    NHP6A
    Gene description
    high-mobility group nucleosome-binding protein
    Primary source
    SGD:S000006256
    Locus tag
    YPR052C
    Gene type
    protein coding
    RNA name
    high-mobility group nucleosome-binding protein
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See NHP6A in Map Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (665693..665974, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene autophagy protein ATG11 Neighboring gene peptide alpha-N-acetyltransferase MAK3 Neighboring gene mitogen-activated protein kinase SMK1 Neighboring gene exocyst subunit SEC8

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with MutSalpha complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    high-mobility group nucleosome-binding protein
    NP_015377.1
    • High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      665693..665974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184149.1NP_015377.1  high-mobility group nucleosome-binding protein [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_015377.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11632
      Conserved Domains (2) summary
      COG5648
      Location:193
      NHP6B; Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]
      cd01390
      Location:2186
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...