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Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 26921, updated on 19-May-2015
Official Symbol
Map4k4provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4provided by MGI
Primary source
MGI:MGI:1349394
See related
Ensembl:ENSMUSG00000026074; Vega:OTTMUSG00000050440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HGK; Nik; AU043147; AU045934; AW046177; 9430080K19Rik
Orthologs
See Map4k4 in MapViewer
Location:
1; 1 B
Exon count:
34
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (39900912..40026310)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (39957758..40083155)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700066B17 gene Neighboring gene predicted gene, 35600 Neighboring gene predicted gene, 16894 Neighboring gene interleukin 1 receptor, type II Neighboring gene predicted gene, 35741

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
creatine kinase activity ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection regeneration ISO
Inferred from Sequence Orthology
more info
 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
response to stress IDA
Inferred from Direct Assay
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
mitogen-activated protein kinase kinase kinase kinase 4
Names
mitogen-activated protein kinase kinase kinase kinase 4
HPK/GCK-like kinase HGK
MAPK/ERK kinase kinase kinase 4
MEK kinase kinase 4
MEKKK 4
NCK interacting kinase
mitogen activated protein kinase kinase kinase kinase 4
nck-interacting kinase
NP_001239129.1
NP_001239130.1
NP_001239131.1
NP_032722.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252200.1NP_001239129.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK159799, AV445090, BB651050, BC145390, BF721981, BQ571658, CJ142598, U88984
    UniProtKB/TrEMBL
    A0A0A6YW53
    UniProtKB/TrEMBL
    B7ZNR8
    UniProtKB/Swiss-Prot
    P97820
    Related
    ENSMUSP00000126961, ENSMUST00000163854
    Conserved Domains (3) summary
    smart00036
    Location:9701268
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  2. NM_001252201.1NP_001239130.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 3

    See identical proteins and their annotated locations for NP_001239130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the presence and absence of in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AK159799, AV445090, BB651050, BC141109, BC145390, BF721981, BQ571658, CJ142598, U88984
    UniProtKB/TrEMBL
    B2RUE8
    UniProtKB/TrEMBL
    B7ZNR8
    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (3) summary
    smart00036
    Location:9031201
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  3. NM_001252202.1NP_001239131.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

    See identical proteins and their annotated locations for NP_001239131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (4), compared to isoform 1.
    Source sequence(s)
    AK159799, AV445090, BB651050, BC145390, BC145391, BF721981, BQ571658, CJ142598, U88984
    UniProtKB/TrEMBL
    B7ZNR8
    UniProtKB/TrEMBL
    B7ZNR9
    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (3) summary
    smart00036
    Location:8901188
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  4. NM_008696.2NP_032722.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_032722.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC132909, AC166238, AK138966, CF531764, U88984
    Consensus CDS
    CCDS35546.1
    UniProtKB/TrEMBL
    A0A0A6YWR8
    UniProtKB/Swiss-Prot
    P97820
    UniProtKB/TrEMBL
    Q3UTY9
    Conserved Domains (3) summary
    smart00036
    Location:9161214
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    39900912..40026310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496041.1XP_006496104.1  

    Conserved Domains (3) summary
    smart00036
    Location:10651363
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  2. XM_011238530.1XP_011236832.1  

    Conserved Domains (3) summary
    smart00036
    Location:10011299
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  3. XM_006496044.1XP_006496107.1  

    UniProtKB/TrEMBL
    F8VPL5
    Related
    ENSMUSP00000129796, OTTMUSP00000068932, ENSMUST00000168431, OTTMUST00000127982
    Conserved Domains (3) summary
    smart00036
    Location:9201218
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  4. XM_006496042.1XP_006496105.1  

    Conserved Domains (3) summary
    smart00036
    Location:10111309
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  5. XM_006496047.1XP_006496110.1  

    Conserved Domains (3) summary
    smart00036
    Location:8701168
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  6. XM_006496045.1XP_006496108.1  

    Conserved Domains (3) summary
    smart00036
    Location:8931191
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  7. XM_006496043.1XP_006496106.1  

    UniProtKB/TrEMBL
    A0A0A6YWM8
    Conserved Domains (3) summary
    smart00036
    Location:9541252
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  8. XM_006496046.1XP_006496109.1  

    Conserved Domains (3) summary
    smart00036
    Location:8381136
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8289
    PKc_like; Catalytic domain of the Protein Kinase superfamily
  9. XM_011238529.1XP_011236831.1  

    Conserved Domains (3) summary
    smart00036
    Location:10091307
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:11234
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1234
    PKc_like; Catalytic domain of the Protein Kinase superfamily

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    39697172..39822126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)