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    SFRP5 secreted frizzled-related protein 5 [ Homo sapiens (human) ]

    Gene ID: 6425, updated on 26-Jun-2015
    Official Symbol
    SFRP5provided by HGNC
    Official Full Name
    secreted frizzled-related protein 5provided by HGNC
    Primary source
    HGNC:HGNC:10779
    See related
    Ensembl:ENSG00000120057; HPRD:09166; MIM:604158; Vega:OTTHUMG00000018866
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SARP3
    Summary
    Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]
    Orthologs
    See SFRP5 in Epigenomics, MapViewer
    Location:
    10q24.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (97766751..97771999, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99526508..99531756, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MARVEL domain containing 1 Neighboring gene zinc finger, FYVE domain containing 27 Neighboring gene long intergenic non-protein coding RNA 866 Neighboring gene golgin A7 family, member B Neighboring gene cartilage acidic protein 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
    NHGRI GWA Catalog
    • DNA replication, organism-specific biosystem (from KEGG)
      DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
    • DNA replication, organism-specific biosystem (from KEGG)
      DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT G-protein coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT Wnt-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    NOT integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    secreted frizzled-related protein 5
    Names
    secreted frizzled-related protein 5
    FRP-1b
    SARP-3
    frizzled-related protein 1b
    sFRP-5
    secreted apoptosis related protein 3
    secreted apoptosis-related protein 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003015.3NP_003006.2  secreted frizzled-related protein 5 precursor

      See identical proteins and their annotated locations for NP_003006.2

      Status: REVIEWED

      Source sequence(s)
      AL358938, BC050435
      Consensus CDS
      CCDS7472.1
      UniProtKB/Swiss-Prot
      Q5T4F7
      Related
      ENSP00000266066, OTTHUMP00000020227, ENST00000266066, OTTHUMT00000049742
      Conserved Domains (2) summary
      cd07444
      Location:47173
      CRD_SFRP5; Cysteine-rich domain of the secreted frizzled-related protein 5 (SFRP5), a regulator of Wnt activity
      cd03580
      Location:178303
      NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

      Range
      97766751..97771999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      99808183..99813431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)