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TLR5 toll-like receptor 5 [ Homo sapiens (human) ]

Gene ID: 7100, updated on 6-Jul-2014
Official Symbol
TLR5provided by HGNC
Official Full Name
toll-like receptor 5provided by HGNC
Primary source
HGNC:11851
Locus tag
RP11-239E10.1
See related
Ensembl:ENSG00000187554; HPRD:04326; MIM:603031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIL3; SLEB1; MELIOS
Summary
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
See TLR5 in Epigenomics, MapViewer
Location:
1q41-q42
Exon count :
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (223109406..223143282, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (223282748..223316624, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dispatched homolog 1 (Drosophila) Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1 pseudogene 2 Neighboring gene uncharacterized LOC102724046 Neighboring gene sushi domain containing 4 Neighboring gene coiled-coil domain containing 185

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Legionellosis
MedGen: C1837872 OMIM: 608556 GeneReviews: Not available
not available
Melioidosis, susceptibility to
MedGen: CN182250 OMIM: 615557 GeneReviews: Not available
not available
Systemic lupus erythematosus 1
MedGen: C1866373 OMIM: 601744 GeneReviews: Not available
not available

Protein interactions

Protein Gene Interaction Pubs
Vif, p23 vif HIV-1 Vif downregulates the expression of toll-like receptor 5 (TLR5) in Vif-expression T cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Legionellosis, organism-specific biosystem (from KEGG)
    Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Legionellosis, conserved biosystem (from KEGG)
    Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
    MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
  • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
    Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
  • Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
    Pathogenic Escherichia coli infection, organism-specific biosystemSources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG]
  • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
    Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
  • Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Regulation of toll-like receptor signaling pathway, organism-specific biosystem
    Regulation of toll-like receptor signaling pathway
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
  • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-1 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response TAS
Traceable Author Statement
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor 10 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor 5 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
toll-like receptor 5
Names
toll-like receptor 5
toll/interleukin-1 receptor-like protein 3
systemic lupus erythematosus susceptibility 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016244.1 

    Range
    5001..38877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003268.5NP_003259.2  toll-like receptor 5 precursor

    See proteins identical to NP_003259.2

    Status: REVIEWED

    Source sequence(s)
    AB060695, AB445645, AL929091, BQ025528, DB448079
    Consensus CDS
    CCDS31033.1
    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (4) summary
    smart00082
    Location:579630
    Blast Score: 90
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:328581
    Blast Score: 141
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:695832
    Blast Score: 310
    TIR; TIR domain
    pfam13855
    Location:314372
    Blast Score: 139
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    223109406..223143282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711506.1XP_006711569.1  

    See proteins identical to XP_006711569.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (4) summary
    smart00082
    Location:579630
    Blast Score: 90
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:328581
    Blast Score: 141
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:695832
    Blast Score: 310
    TIR; TIR domain
    pfam13855
    Location:314372
    Blast Score: 139
    LRR_8; Leucine rich repeat
  2. XM_006711505.1XP_006711568.1  

    See proteins identical to XP_006711568.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (4) summary
    smart00082
    Location:579630
    Blast Score: 90
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:328581
    Blast Score: 141
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:695832
    Blast Score: 310
    TIR; TIR domain
    pfam13855
    Location:314372
    Blast Score: 139
    LRR_8; Leucine rich repeat
  3. XM_006711504.1XP_006711567.1  

    See proteins identical to XP_006711567.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (4) summary
    smart00082
    Location:579630
    Blast Score: 90
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:328581
    Blast Score: 141
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:695832
    Blast Score: 310
    TIR; TIR domain
    pfam13855
    Location:314372
    Blast Score: 139
    LRR_8; Leucine rich repeat
  4. XM_005273242.2XP_005273299.2  

    See proteins identical to XP_005273299.2

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (4) summary
    smart00082
    Location:579630
    Blast Score: 90
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:328581
    Blast Score: 141
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:695832
    Blast Score: 310
    TIR; TIR domain
    pfam13855
    Location:314372
    Blast Score: 139
    LRR_8; Leucine rich repeat
  5. XM_005273243.2XP_005273300.2  

    See proteins identical to XP_005273300.2

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (4) summary
    smart00082
    Location:579630
    Blast Score: 90
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:328581
    Blast Score: 141
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:695832
    Blast Score: 310
    TIR; TIR domain
    pfam13855
    Location:314372
    Blast Score: 139
    LRR_8; Leucine rich repeat
  6. XM_005273241.2XP_005273298.2  

    See proteins identical to XP_005273298.2

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (4) summary
    smart00082
    Location:579630
    Blast Score: 90
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:328581
    Blast Score: 141
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:695832
    Blast Score: 310
    TIR; TIR domain
    pfam13855
    Location:314372
    Blast Score: 139
    LRR_8; Leucine rich repeat
  7. XM_006711507.1XP_006711570.1  

    See proteins identical to XP_006711570.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (4) summary
    smart00082
    Location:579630
    Blast Score: 90
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:328581
    Blast Score: 141
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:695832
    Blast Score: 310
    TIR; TIR domain
    pfam13855
    Location:314372
    Blast Score: 139
    LRR_8; Leucine rich repeat
  8. XM_006711503.1XP_006711566.1  

    See proteins identical to XP_006711566.1

    UniProtKB/Swiss-Prot
    O60602
    Conserved Domains (4) summary
    smart00082
    Location:579630
    Blast Score: 90
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:328581
    Blast Score: 141
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam01582
    Location:695832
    Blast Score: 310
    TIR; TIR domain
    pfam13855
    Location:314372
    Blast Score: 139
    LRR_8; Leucine rich repeat

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    193957238..193991230
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    224555804..224589771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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