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    LGALS1 galectin 1 [ Homo sapiens (human) ]

    Gene ID: 3956, updated on 22-Sep-2016
    Official Symbol
    LGALS1provided by HGNC
    Official Full Name
    galectin 1provided by HGNC
    Primary source
    HGNC:HGNC:6561
    See related
    Ensembl:ENSG00000100097 HPRD:01040; MIM:150570; Vega:OTTHUMG00000150661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GBP; GAL1
    Summary
    The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    22q13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 22 NC_000022.11 (37675606..37679802)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38071613..38075809)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene pyridoxal phosphatase Neighboring gene RNA, 7SL, cytoplasmic 385, pseudogene Neighboring gene nucleolar protein 12 Neighboring gene TRIO and F-actin binding protein Neighboring gene uncharacterized LOC102724378

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Galectin 1 binds to HIV-1 gp120 by recognizing clustered CX glycan patches of gp120 in a beta-galactoside-dependent manner. CD4 plays a role as a ligand for the binding between Galectin 1 and gp120 PubMed
    env Galectin-1, a dimeric beta-galactoside-binding protein, promotes infection with CCR5-tropic, CXCR4-tropic, and CCR5/CXCR4 dual-tropic HIV-1 variants by facilitating attachment of HIV-1 gp120 to CD4 at the cell surface PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp686E23103

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    glycoprotein binding IEA
    Inferred from Electronic Annotation
    more info
     
    lactose binding IEA
    Inferred from Electronic Annotation
    more info
     
    laminin binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    myoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    plasma cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT positive regulation of dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of erythrocyte aggregation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    galectin-1
    Names
    14 kDa laminin-binding protein
    14 kDa lectin
    HBL
    HLBP14
    HPL
    S-Lac lectin 1
    beta-galactoside-binding lectin L-14-I
    beta-galactoside-binding protein 14kDa
    gal-1
    galaptin
    lactose-binding lectin 1
    lectin, galactoside-binding, soluble, 1
    putative MAPK-activating protein PM12

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002305.3NP_002296.1  galectin-1

      See identical proteins and their annotated locations for NP_002296.1

      Status: REVIEWED

      Source sequence(s)
      BC020675, CR456511
      Consensus CDS
      CCDS13954.1
      UniProtKB/Swiss-Prot
      P09382
      Related
      ENSP00000215909, OTTHUMP00000198176, ENST00000215909, OTTHUMT00000319482
      Conserved Domains (1) summary
      smart00276
      Location:11134
      GLECT; Galectin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p7 Primary Assembly

      Range
      37675606..37679802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018933.2 Alternate CHM1_1.1

      Range
      38030320..38034516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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