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Grm5 glutamate receptor, metabotropic 5 [ Mus musculus (house mouse) ]

Gene ID: 108071, updated on 26-Aug-2014
Official Symbol
Grm5provided by MGI
Official Full Name
glutamate receptor, metabotropic 5provided by MGI
Primary source
MGI:1351342
See related
Ensembl:ENSMUSG00000049583; Vega:OTTMUSG00000016489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glu5R; Gprc1e; mGluR5; mGluR5b; AI850523; 6430542K11Rik
See Grm5 in Epigenomics, MapViewer
Location:
7 E1; 7
Exon count:
12
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 7 NC_000073.6 (87583979..88135063)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene NADPH oxidase 4 Neighboring gene tyrosinase Neighboring gene splicing factor 3a, subunit 1 pseudogene Neighboring gene cathepsin C Neighboring gene predicted gene 2407

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
A2A adenosine receptor binding ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
PLC activating G-protein coupled glutamate receptor activity TAS
Traceable Author Statement
more info
PubMed 
glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
G-protein coupled glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of MAPKKK activity ISO
Inferred from Sequence Orthology
more info
 
cognition ISO
Inferred from Sequence Orthology
more info
 
desensitization of G-protein coupled receptor protein signaling pathway ISO
Inferred from Sequence Orthology
more info
 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of locomotion ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating G-protein coupled glutamate receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
protein kinase C-activating G-protein coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
protein kinase C-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
metabotropic glutamate receptor 5
Names
metabotropic glutamate receptor 5
G protein-coupled receptor GRM5
metabotropic glutamate receptor type 5
metabotropic glutamate receptor subtype 5b
G protein coupled receptor, family C, group 1, member E
G protein-coupled receptor, family C, group 1, member E

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081414.2NP_001074883.1  metabotropic glutamate receptor 5 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) lacks an alternate in-frame exon in the 3' coding region, compared to variant b. The resulting isoform (a) lacks a segment near the C-terminus, compared to isoform b.
    Source sequence(s)
    AC113033, BC096533, BC144727, BY721282, CJ124875
    Consensus CDS
    CCDS40013.1
    UniProtKB/TrEMBL
    B7ZMP7
    UniProtKB/TrEMBL
    E9QMC2
    UniProtKB/TrEMBL
    Q4VA56
    Related
    ENSMUSP00000118393, OTTMUSP00000017749, ENSMUST00000125009, OTTMUST00000039787
    Conserved Domains (5) summary
    cd06374
    Location:26496
    Blast Score: 2412
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam10606
    Location:11211171
    Blast Score: 242
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
    pfam00003
    Location:588824
    Blast Score: 731
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67471
    Blast Score: 732
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:507557
    Blast Score: 216
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  2. NM_001143834.1NP_001137306.1  metabotropic glutamate receptor 5 isoform b precursor

    See proteins identical to NP_001137306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) represents the longer transcript and encodes the longer isoform (b).
    Source sequence(s)
    AC113033, AC116820, BC096533, BY721282, CJ124875
    Consensus CDS
    CCDS52305.1
    UniProtKB/TrEMBL
    B2BH30
    UniProtKB/Swiss-Prot
    Q3UVX5
    UniProtKB/TrEMBL
    Q4VA56
    Conserved Domains (5) summary
    cd06374
    Location:26496
    Blast Score: 2412
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam10606
    Location:11531203
    Blast Score: 243
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
    pfam00003
    Location:588824
    Blast Score: 735
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67471
    Blast Score: 732
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:507557
    Blast Score: 216
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000073.6 

    Range
    87583979..88135063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507182.1XP_006507245.1  

    See proteins identical to XP_006507245.1

    UniProtKB/TrEMBL
    B2BH30
    UniProtKB/Swiss-Prot
    Q3UVX5
    Conserved Domains (5) summary
    cd06374
    Location:26496
    Blast Score: 2412
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam10606
    Location:11531203
    Blast Score: 243
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
    pfam00003
    Location:588824
    Blast Score: 735
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67471
    Blast Score: 732
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:507557
    Blast Score: 216
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  2. XM_006507183.1XP_006507246.1  

    See proteins identical to XP_006507246.1

    UniProtKB/TrEMBL
    B2BH30
    UniProtKB/Swiss-Prot
    Q3UVX5
    Conserved Domains (5) summary
    cd06374
    Location:26496
    Blast Score: 2412
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam10606
    Location:11531203
    Blast Score: 243
    GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor
    pfam00003
    Location:588824
    Blast Score: 735
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67471
    Blast Score: 732
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:507557
    Blast Score: 216
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  3. XM_006507184.1XP_006507247.1  

    Conserved Domains (4) summary
    cd06374
    Location:26496
    Blast Score: 2412
    PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
    pfam00003
    Location:588824
    Blast Score: 728
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:67471
    Blast Score: 732
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:507557
    Blast Score: 215
    NCD3G; Nine Cysteines Domain of family 3 GPCR

Alternate Mm_Celera

Genomic

  1. AC_000029.1 

    Range
    84945210..85487922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033224.1: Suppressed sequence

    Description
    NM_001033224.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.