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    Trib3 tribbles pseudokinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246273, updated on 10-Apr-2016
    Official Symbol
    Trib3provided by RGD
    Official Full Name
    tribbles pseudokinase 3provided by RGD
    Primary source
    RGD:708432
    See related
    Ensembl:ENSRNOG00000007319
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NIPK
    Summary
    putative kinase; expression upregulated by NGF-depletion induced programmed cell death [RGD, Feb 2006]
    Orthologs
    Location:
    3q41
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (147814056..147819650, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (154162197..154167791, complement)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 20 Neighboring gene RANBP2-type and C3HC4-type zinc finger containing 1 Neighboring gene neurensin 2 Neighboring gene SRY box 12

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • Insulin resistance, organism-specific biosystem (from KEGG)
      Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NOT kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    programmed cell death NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of MAP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of glucose transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of glucose transport ISO
    Inferred from Sequence Orthology
    more info
     
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    tribbles homolog 3
    Names
    Neuronal cell death Inducible Putative Kinase
    TRB-3
    kinase
    neuronal cell death-inducible putative kinase

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144755.2NP_653356.1  tribbles homolog 3

      See identical proteins and their annotated locations for NP_653356.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091120
      UniProtKB/Swiss-Prot
      Q9WTQ6
      Related
      ENSRNOP00000009840, ENSRNOT00000009840
      Conserved Domains (2) summary
      smart00220
      Location:126310
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:69310
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      147814056..147819650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      139561433..139567041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)