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Gata2 GATA binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 14461, updated on 26-Aug-2014
Official Symbol
Gata2provided by MGI
Official Full Name
GATA binding protein 2provided by MGI
Primary source
MGI:95662
See related
Ensembl:ENSMUSG00000015053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gata-2
See Gata2 in Epigenomics, MapViewer
Location:
6 D1; 6 39.2 cM
Exon count:
7
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 6 NC_000072.6 (88192543..88207032)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102638270 Neighboring gene RAB7, member RAS oncogene family Neighboring gene ribophorin I Neighboring gene microRNA mir-6376 Neighboring gene uncharacterized LOC102638585 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 8 Neighboring gene eukaryotic elongation factor, selenocysteine-tRNA-specific

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC129339

Gene Ontology Provided by MGI

Function Evidence Code Pubs
C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II distal enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
GABAergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation in hindbrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate determination IDA
Inferred from Direct Assay
more info
PubMed 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
commitment of neuronal cell to specific neuron type in forebrain IMP
Inferred from Mutant Phenotype
more info
 
definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
eosinophil fate commitment ISO
Inferred from Sequence Orthology
more info
 
homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of macrophage differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis ISO
Inferred from Sequence Orthology
more info
 
pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of megakaryocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of forebrain neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 
regulation of histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
semicircular canal development IMP
Inferred from Mutant Phenotype
more info
 
somatic stem cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
urogenital system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventral spinal cord interneuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
endothelial transcription factor GATA-2
Names
endothelial transcription factor GATA-2
GATA-binding protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008090.5NP_032116.4  endothelial transcription factor GATA-2

    See proteins identical to NP_032116.4

    Status: VALIDATED

    Source sequence(s)
    AB000096, AW492264, BC107009, BY132907
    Consensus CDS
    CCDS20333.1
    UniProtKB/Swiss-Prot
    O09100
    UniProtKB/TrEMBL
    Q3U320
    Related
    ENSMUSP00000015197, ENSMUST00000015197
    Conserved Domains (1) summary
    cd00202
    Location:349398
    Blast Score: 203
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000072.6 

    Range
    88192543..88207032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505539.1XP_006505602.1  

    See proteins identical to XP_006505602.1

    UniProtKB/Swiss-Prot
    O09100
    UniProtKB/TrEMBL
    Q3U320
    Conserved Domains (1) summary
    cd00202
    Location:349398
    Blast Score: 203
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

Alternate Mm_Celera

Genomic

  1. AC_000028.1 

    Range
    90136051..90144243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)