Display Settings:

Format

Send to:

Choose Destination

SLC19A1 solute carrier family 19 (folate transporter), member 1 [ Homo sapiens (human) ]

Gene ID: 6573, updated on 13-Sep-2014
Official Symbol
SLC19A1provided by HGNC
Official Full Name
solute carrier family 19 (folate transporter), member 1provided by HGNC
Primary source
HGNC:HGNC:10937
See related
Ensembl:ENSG00000173638; HPRD:02691; MIM:600424; Vega:OTTHUMG00000090397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHMD; FOLT; IFC1; REFC; RFC1
Summary
The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
See SLC19A1 in Epigenomics, MapViewer
Location:
21q22.3
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 21 NC_000021.9 (45514715..45542471, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46934629..46983045, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene collagen, type XVIII, alpha 1 Neighboring gene uncharacterized LOC101928717 Neighboring gene microRNA 6815 Neighboring gene uncharacterized LOC100129027 Neighboring gene poly(rC) binding protein 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
folic acid binding IEA
Inferred from Electronic Annotation
more info
 
folic acid transporter activity IEA
Inferred from Electronic Annotation
more info
 
methotrexate transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
folic acid metabolic process TAS
Traceable Author Statement
more info
 
folic acid transport IEA
Inferred from Electronic Annotation
more info
 
methotrexate transport IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
vitamin metabolic process TAS
Traceable Author Statement
more info
 
water-soluble vitamin metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
folate transporter 1
Names
folate transporter 1
RFC
IFC-1
intestinal folate carrier 1
placental folate transporter
reduced folate carrier protein
solute carrier family 19 member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028278.1 

    Range
    5001..32757
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001205206.1NP_001192135.1  folate transporter 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK307623, AK313125, BC003068
    Consensus CDS
    CCDS56218.1
    UniProtKB/Swiss-Prot
    P41440
    Related
    ENSP00000369347, OTTHUMP00000115460, ENST00000380010, OTTHUMT00000206797
    Conserved Domains (3) summary
    cd06174
    Location:264419
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00806
    Location:1431
    rfc; RFC reduced folate carrier
    pfam01770
    Location:24431
    Folate_carrier; Reduced folate carrier
  2. NM_001205207.1NP_001192136.1  folate transporter 1 isoform 3

    See proteins identical to NP_001192136.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK303168, DC311922, U19720
    Consensus CDS
    CCDS56217.1
    UniProtKB/Swiss-Prot
    P41440
    Conserved Domains (3) summary
    cd06174
    Location:224412
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00806
    Location:23466
    rfc; RFC reduced folate carrier
    pfam01770
    Location:23392
    Folate_carrier; Reduced folate carrier
  3. NM_194255.2NP_919231.1  folate transporter 1 isoform 1

    See proteins identical to NP_919231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK307623, AK313125, U19720
    Consensus CDS
    CCDS13725.1
    UniProtKB/Swiss-Prot
    P41440
    Related
    ENSP00000478997, ENST00000477688
    Conserved Domains (3) summary
    cd06174
    Location:264452
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00806
    Location:1506
    rfc; RFC reduced folate carrier
    pfam01770
    Location:24432
    Folate_carrier; Reduced folate carrier

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000021.9 

    Range
    45514715..45542471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261164.1XP_005261221.1  

    See proteins identical to XP_005261221.1

    Conserved Domains (2) summary
    cd06174
    Location:146334
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00806
    Location:1388
    rfc; RFC reduced folate carrier

Alternate HuRef

Genomic

  1. AC_000153.1 

    Range
    32311090..32338803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018932.2 

    Range
    46495459..46523222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003056.2: Suppressed sequence

    Description
    NM_003056.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.