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    Foxp3 forkhead box P3 [ Mus musculus (house mouse) ]

    Gene ID: 20371, updated on 23-Aug-2016
    Official Symbol
    Foxp3provided by MGI
    Official Full Name
    forkhead box P3provided by MGI
    Primary source
    MGI:MGI:1891436
    See related
    Ensembl:ENSMUSG00000039521 Vega:OTTMUSG00000016624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sf; JM2; scurfin
    Summary
    The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    X A1.1; X 3.41 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (7579676..7595243)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (7156819..7172360)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene kelch-like 21 pseudogene Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 3F Neighboring gene protein phosphatase 1, regulatory subunit 3F, opposite strand Neighboring gene coiled-coil domain containing 22 Neighboring gene calcium channel, voltage-dependent, alpha 1F subunit Neighboring gene synaptophysin

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
      Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    NFAT protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    T cell mediated immunity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myeloid cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of CREB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T-helper 17 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of chronic inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of chronic inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cytokine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cytokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of histone deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of immune response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interferon-gamma biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interferon-gamma production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-2 biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-2 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-2 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-4 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-4 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-4 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-5 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of interleukin-5 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of isotype switching to IgE isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of T cell anergy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell tolerance induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of immature T cell proliferation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-4 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peripheral T cell tolerance induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of regulatory T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transforming growth factor beta1 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of T cell anergy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    regulatory T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tolerance induction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tolerance induction to self antigen IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    forkhead box protein P3
    Names
    scurfy

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199347.1NP_001186276.1  forkhead box protein P3

      See identical proteins and their annotated locations for NP_001186276.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AF277992, AL672231, AL731793
      Consensus CDS
      CCDS29965.1
      UniProtKB/Swiss-Prot
      Q99JB6
      UniProtKB/TrEMBL
      Q53Z59
      Related
      ENSMUSP00000111405, OTTMUSP00000017952, ENSMUST00000115740, OTTMUST00000040205
      Conserved Domains (2) summary
      pfam00250
      Location:337410
      Forkhead; Forkhead domain
      pfam16159
      Location:192259
      FOXP-CC; FOXP coiled-coil domain
    2. NM_001199348.1NP_001186277.1  forkhead box protein P3

      See identical proteins and their annotated locations for NP_001186277.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AF277991, AL672231
      Consensus CDS
      CCDS29965.1
      UniProtKB/Swiss-Prot
      Q99JB6
      UniProtKB/TrEMBL
      Q53Z59
      Related
      ENSMUSP00000111403, OTTMUSP00000017962, ENSMUST00000115738, OTTMUST00000040222
      Conserved Domains (2) summary
      pfam00250
      Location:337410
      Forkhead; Forkhead domain
      pfam16159
      Location:192259
      FOXP-CC; FOXP coiled-coil domain
    3. NM_054039.2NP_473380.1  forkhead box protein P3

      See identical proteins and their annotated locations for NP_473380.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AF277992, AL672231, AL731793
      Consensus CDS
      CCDS29965.1
      UniProtKB/Swiss-Prot
      Q99JB6
      UniProtKB/TrEMBL
      Q53Z59
      Related
      ENSMUSP00000111404, OTTMUSP00000017961, ENSMUST00000115739, OTTMUST00000040221
      Conserved Domains (2) summary
      pfam00250
      Location:337410
      Forkhead; Forkhead domain
      pfam16159
      Location:192259
      FOXP-CC; FOXP coiled-coil domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      7579676..7595243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)