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App amyloid beta (A4) precursor protein [ Mus musculus (house mouse) ]

Gene ID: 11820, updated on 19-Dec-2014
Official Symbol
Appprovided by MGI
Official Full Name
amyloid beta (A4) precursor proteinprovided by MGI
Primary source
MGI:MGI:88059
See related
Ensembl:ENSMUSG00000022892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik
Location:
16 C3-qter; 16 46.92 cM
Exon count:
19
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 16 NC_000082.6 (84954436..85173952, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene junction adhesion molecule 2 Neighboring gene predicted gene, 32129 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F Neighboring gene GA repeat binding protein, alpha Neighboring gene predicted gene 10791 Neighboring gene predicted gene, 32251 Neighboring gene predicted gene, 32314 Neighboring gene cysteine and tyrosine-rich protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
PTB domain binding ISO
Inferred from Sequence Orthology
more info
 
acetylcholine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peptidase activator activity ISO
Inferred from Sequence Orthology
more info
 
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
axon cargo transport IGI
Inferred from Genetic Interaction
more info
PubMed 
axon cargo transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT axon cargo transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon midline choice point recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular copper ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
collateral sprouting in absence of injury IGI
Inferred from Genetic Interaction
more info
PubMed 
dendrite development IGI
Inferred from Genetic Interaction
more info
PubMed 
dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ionotropic glutamate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
mRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
mating behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epidermal growth factor-activated receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein binding IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synapse structure or activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
smooth endoplasmic reticulum calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
suckling behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
synaptic growth at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cell IGI
Inferred from Genetic Interaction
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
ciliary rootlet IDA
Inferred from Direct Assay
more info
PubMed 
coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope lumen ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
smooth endoplasmic reticulum IGI
Inferred from Genetic Interaction
more info
PubMed 
spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
amyloid beta A4 protein
Names
amyloid beta A4 protein
appican
protease nexin II
amyloidogenic glycoprotein
alzheimer disease amyloid A4 protein homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198823.1NP_001185752.1  amyloid beta A4 protein isoform 1 precursor

    See proteins identical to NP_001185752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK128971, AK159718, BC070409, BP753972
    UniProtKB/Swiss-Prot
    P12023
    UniProtKB/TrEMBL
    Q3TWF3
    UniProtKB/TrEMBL
    Q6GR78
    Conserved Domains (7) summary
    pfam03494
    Location:682713
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    cd00109
    Location:295342
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:715766
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:365549
    APP_E2; E2 domain of amyloid precursor protein
  2. NM_001198824.1NP_001185753.1  amyloid beta A4 protein isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, AK133639, BC070409, BP753972
    UniProtKB/TrEMBL
    Q6GR78
    Conserved Domains (7) summary
    pfam03494
    Location:663694
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    cd00109
    Location:295342
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:696747
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:346530
    APP_E2; E2 domain of amyloid precursor protein
  3. NM_001198825.1NP_001185754.1  amyloid beta A4 protein isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, AK133639, BC070409, BP753972
    UniProtKB/TrEMBL
    Q6GR78
    Conserved Domains (7) summary
    pfam03494
    Location:645676
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    cd00109
    Location:295342
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:678729
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:346530
    APP_E2; E2 domain of amyloid precursor protein
  4. NM_001198826.1NP_001185755.1  amyloid beta A4 protein isoform 6 precursor

    See proteins identical to NP_001185755.1

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, AK159718, BC070409, BP753972
    UniProtKB/TrEMBL
    Q3TWF3
    UniProtKB/TrEMBL
    Q6GR78
    Conserved Domains (7) summary
    pfam03494
    Location:664695
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    cd00109
    Location:295342
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:697748
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:365549
    APP_E2; E2 domain of amyloid precursor protein
  5. NM_007471.3NP_031497.2  amyloid beta A4 protein isoform 2 precursor

    See proteins identical to NP_031497.2

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, BC070409, BP753972
    Consensus CDS
    CCDS28285.1
    UniProtKB/TrEMBL
    Q6GR78
    Related
    ENSMUSP00000005406, ENSMUST00000005406
    Conserved Domains (6) summary
    pfam03494
    Location:607638
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:640691
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:290474
    APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000082.6 

    Range
    84954436..85173952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522873.1XP_006522936.1  

    Conserved Domains (6) summary
    pfam03494
    Location:589620
    Beta-APP; Beta-amyloid peptide (beta-APP)
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:622673
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:290474
    APP_E2; E2 domain of amyloid precursor protein
  2. XM_006522874.1XP_006522937.1  

    Conserved Domains (5) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12924
    Location:132188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    cd00109
    Location:295342
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam02177
    Location:30131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam12925
    Location:365549
    APP_E2; E2 domain of amyloid precursor protein

Alternate Mm_Celera

Genomic

  1. AC_000038.1 

    Range
    85161859..85329235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)