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ROCK2 Rho-associated, coiled-coil containing protein kinase 2 [ Homo sapiens (human) ]

Gene ID: 9475, updated on 24-Jan-2015
Official Symbol
ROCK2provided by HGNC
Official Full Name
Rho-associated, coiled-coil containing protein kinase 2provided by HGNC
Primary source
HGNC:HGNC:10252
See related
Ensembl:ENSG00000134318; HPRD:04922; MIM:604002; Vega:OTTHUMG00000149916
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ROCK-II
Summary
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]
Orthologs
See ROCK2 in MapViewer
Location:
2p24
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (11179768..11344585, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (11319894..11484711, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene chromosome 2 open reading frame 50 Neighboring gene PQ loop repeat containing 3 Neighboring gene axin interactor, dorsalization associated pseudogene Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene long intergenic non-protein coding RNA 570

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Filamin-A-dependent activation of the RhoA-ROCK-LIMK-cofilin pathway is a major event in HIV-1 gp120-induced receptor clustering PubMed
matrix gag HIV-1 p17-mediated activation of the Rho/ROCK-signaling pathway is required for p17-mediated monocyte adhesion and migration PubMed
gag HIV-1 p17-induced activation of PTEN is regulated by RhoA-associated kinase (ROCK) PubMed

Go to the HIV-1, Human Interaction Database

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    Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
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    Pathways in cancer, organism-specific biosystem
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    Plasma membrane estrogen receptor signaling, organism-specific biosystem
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  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
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  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
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  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
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  • RhoA signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    RhoA signaling pathway, organism-specific biosystem
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  • Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
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  • Semaphorin interactions, organism-specific biosystem (from REACTOME)
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  • Shigellosis, organism-specific biosystem (from KEGG)
    Shigellosis, organism-specific biosystemShigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestina...
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  • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0619

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Rho GTPase binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
structural molecule activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
centrosome duplication IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokinesis NAS
Non-traceable Author Statement
more info
PubMed 
dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
regulation of cell adhesion TAS
Traceable Author Statement
more info
PubMed 
regulation of cell motility TAS
Traceable Author Statement
more info
PubMed 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of establishment of cell polarity TAS
Traceable Author Statement
more info
PubMed 
regulation of focal adhesion assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of stress fiber assembly TAS
Traceable Author Statement
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contraction TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
spindle pole centrosome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
rho-associated protein kinase 2
Names
rho-associated protein kinase 2
p164 ROCK-2
rho-associated, coiled-coil-containing protein kinase II
NP_004841.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029769.1 

    Range
    5001..167934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004850.3NP_004841.2  rho-associated protein kinase 2

    See proteins identical to NP_004841.2

    Status: REVIEWED

    Source sequence(s)
    AB014519, BG539531, CD652480, D87931
    Consensus CDS
    CCDS42654.1
    UniProtKB/Swiss-Prot
    O75116
    Conserved Domains (7) summary
    pfam01576
    Location:4431124
    Myosin_tail_1; Myosin tail
    pfam08912
    Location:9791046
    Rho_Binding; Rho Binding
    cd11638
    Location:505571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:92354
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:12611307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:11511257
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cd05621
    Location:39417
    STKc_ROCK2; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    11179768..11344585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246190.2XP_005246247.1  

    Related
    ENSP00000317985, OTTHUMP00000195104, ENST00000315872, OTTHUMT00000313886
    Conserved Domains (9) summary
    pfam01576
    Location:4431124
    Myosin_tail_1; Myosin tail
    pfam08912
    Location:9791046
    Rho_Binding; Rho Binding
    cd05596
    Location:48417
    STKc_ROCK; Catalytic domain of the Protein Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase
    pfam04799
    Location:550624
    Fzo_mitofusin; fzo-like conserved region
    cd11638
    Location:505571
    HR1_ROCK2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2
    smart00220
    Location:92354
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:12611307
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01242
    Location:11511273
    PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
    cl19113
    Location:8171001
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    11251294..11414170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    11171519..11335102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)