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    ALDH1A1 aldehyde dehydrogenase 1 family member A1 [ Homo sapiens (human) ]

    Gene ID: 216, updated on 19-Jul-2016
    Official Symbol
    ALDH1A1provided by HGNC
    Official Full Name
    aldehyde dehydrogenase 1 family member A1provided by HGNC
    Primary source
    HGNC:HGNC:402
    See related
    Ensembl:ENSG00000165092 HPRD:00001; MIM:100640; Vega:OTTHUMG00000020019
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e
    Summary
    The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]
    Orthologs
    Location:
    9q21.13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (72900662..72953317, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (75515578..75653633, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene transmembrane channel like 1 Neighboring gene ribosomal protein S27a pseudogene 15 Neighboring gene long intergenic non-protein coding RNA 1474 Neighboring gene cytochrome P450 family 1 subfamily D member 1, pseudogene Neighboring gene uncharacterized LOC105376081

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of aldehyde dehydrogenase 1 family, member A1 (ALDH1A1) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    • Biological oxidations, organism-specific biosystem (from REACTOME)
      Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
    • Ethanol oxidation, organism-specific biosystem (from REACTOME)
      Ethanol oxidation, organism-specific biosystemEthanol and related alcohols can be ingested as part of the diet and are formed by microorganisms in the intestinal tract. Ethanol oxidation to acetate occurs primarily in liver cells in a multistep ...
    • Fatty Acid Omega Oxidation, organism-specific biosystem (from WikiPathways)
      Fatty Acid Omega Oxidation, organism-specific biosystem
      Fatty Acid Omega Oxidation
    • Folate-Alcohol and Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Folate-Alcohol and Cancer Pathway, organism-specific biosystem
      Folate-Alcohol and Cancer Pathway
    • Fructose catabolism, organism-specific biosystem (from REACTOME)
      Fructose catabolism, organism-specific biosystemFructose occurs naturally in foods as a free monosaccharide and as a component of the disaccharide sucrose. It is also widely used as a sweetener. In the body, fructose catabolism occurs in the liver...
    • Fructose metabolism, organism-specific biosystem (from REACTOME)
      Fructose metabolism, organism-specific biosystemFructose is found in fruits, is one of the components of the disaccharide sucrose, and is a widely used sweetener in processed foods. Dietary fructose is catabolized in the liver via fructose 1-phosp...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
      Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
    • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
      Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
    • RA biosynthesis pathway, organism-specific biosystem (from REACTOME)
      RA biosynthesis pathway, organism-specific biosystemThe major activated retinoid, all-trans-retinoic acid (atRA) is produced by the dehydrogenation of all-trans-retinol (atROL) by members of the short chain dehydrogenase/reductase (SDR) and aldehyde d...
    • Retinol metabolism, organism-specific biosystem (from KEGG)
      Retinol metabolism, organism-specific biosystem
      Retinol metabolism
    • Retinol metabolism, conserved biosystem (from KEGG)
      Retinol metabolism, conserved biosystem
      Retinol metabolism
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Retinoic Acid, organism-specific biosystem (from REACTOME)
      Signaling by Retinoic Acid, organism-specific biosystemVitamin A (retinol) can be metabolised into active retinoid metabolites that function either as a chromophore in vision or in regulating gene expression transcriptionally and post-transcriptionally. ...
    • Tryptophan metabolism, organism-specific biosystem (from WikiPathways)
      Tryptophan metabolism, organism-specific biosystem
      Tryptophan metabolism
    • Vitamin A and carotenoid metabolism, organism-specific biosystem (from WikiPathways)
      Vitamin A and carotenoid metabolism, organism-specific biosystemThis pathway is about carotenoid and vitamin A metabolism. The initial version was created by the NuGO focusteam on Carotenoid metabolism. It was used to test a text mining workflow which added some ...
    • retinoate biosynthesis I, conserved biosystem (from BIOCYC)
      retinoate biosynthesis I, conserved biosystemGeneral Background |FRAME: RETINOATE "All-trans retinoic acid"|, one of the forms of vitamin A, is a metabolite of |FRAME: CPD-13524| that mediates the functions of vitamin A required for growth and...
    • retinoate biosynthesis I, organism-specific biosystem (from BIOCYC)
      retinoate biosynthesis I, organism-specific biosystem
      retinoate biosynthesis I
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC2318

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    aldehyde dehydrogenase (NAD) activity EXP
    Inferred from Experiment
    more info
    PubMed 
    aldehyde dehydrogenase (NAD) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    androgen binding TAS
    Traceable Author Statement
    more info
    PubMed 
    benzaldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    retinal dehydrogenase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    cellular aldehyde metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    ethanol oxidation TAS
    Traceable Author Statement
    more info
     
    fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate TAS
    Traceable Author Statement
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    retinal dehydrogenase 1
    Names
    ALDH class 1
    ALHDII
    RALDH 1
    acetaldehyde dehydrogenase 1
    aldehyde dehydrogenase 1 family, member A1
    aldehyde dehydrogenase 1, soluble
    aldehyde dehydrogenase, liver cytosolic
    epididymis luminal protein 12
    epididymis luminal protein 9
    epididymis secretory sperm binding protein Li 53e
    retinaldehyde dehydrogenase 1
    NP_000680.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012249.1 RefSeqGene

      Range
      4737..57392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000689.4NP_000680.2  retinal dehydrogenase 1

      See identical proteins and their annotated locations for NP_000680.2

      Status: REVIEWED

      Source sequence(s)
      AI074764, BC001505, DC398835
      Consensus CDS
      CCDS6644.1
      UniProtKB/Swiss-Prot
      P00352
      UniProtKB/TrEMBL
      V9HW83
      Related
      ENSP00000297785, OTTHUMP00000021482, ENST00000297785, OTTHUMT00000052679
      Conserved Domains (1) summary
      cd07141
      Location:15495
      ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      72900662..72953317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      75662616..75715255 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)