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EPHA4 EPH receptor A4 [ Homo sapiens (human) ]

Gene ID: 2043, updated on 14-Feb-2015
Official Symbol
EPHA4provided by HGNC
Official Full Name
EPH receptor A4provided by HGNC
Primary source
HGNC:HGNC:3388
See related
Ensembl:ENSG00000116106; HPRD:03719; MIM:602188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEK; HEK8; TYRO1
Summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Orthologs
See EPHA4 in MapViewer
Location:
2q36.1
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (221418027..221572290, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (222282747..222437010, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microRNA 4268 Neighboring gene uncharacterized LOC101928662 Neighboring gene uncharacterized LOC729770 Neighboring gene ribosomal protein L23 pseudogene 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
NHGRI GWA Catalog
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
NHGRI GWA Catalog
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
    EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
  • EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHA forward signaling, organism-specific biosystem
    EPHA forward signaling
  • EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
    EPHA-mediated growth cone collapse, organism-specific biosystemEPH/Ephrin signaling is coupled to Rho family GTPases such as Rac, Rho and Cdc42 that connect bidirectional receptor-ligand interactions to changes in the actin cytoskeleton (Noren & Pasquale 2004, G...
  • EphrinA-EPHA pathway, organism-specific biosystem (from Pathway Interaction Database)
    EphrinA-EPHA pathway, organism-specific biosystem
    EphrinA-EPHA pathway
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DH domain binding IDA
Inferred from Direct Assay
more info
PubMed 
GPI-linked ephrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
PH domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane-ephrin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
adult walking behavior IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
corticospinal tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
fasciculation of motor neuron axon ISS
Inferred from Sequence or Structural Similarity
more info
 
fasciculation of sensory neuron axon ISS
Inferred from Sequence or Structural Similarity
more info
 
glial cell migration IEA
Inferred from Electronic Annotation
more info
 
motor neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of axon regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of Rho guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of astrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
axon terminus IEA
Inferred from Electronic Annotation
more info
 
axonal growth cone IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
early endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
filopodium IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ephrin type-A receptor 4
Names
ephrin type-A receptor 4
EK8
EPH-like kinase 8
TYRO1 protein tyrosine kinase
receptor protein-tyrosine kinase HEK8
tyrosine-protein kinase TYRO1
tyrosine-protein kinase receptor SEK
NP_004429.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304536.1NP_001291465.1  ephrin type-A receptor 4 isoform a precursor

    See proteins identical to NP_001291465.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC010899, AK290306, BC105000, BM676153
    Conserved Domains (7) summary
    cd09545
    Location:911981
    SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
    smart00454
    Location:915975
    SAM; Sterile alpha motif
    cd10482
    Location:30203
    EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
    cd00063
    Location:441532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:621878
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:562618
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cd05066
    Location:616882
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
  2. NM_001304537.1NP_001291466.1  ephrin type-A receptor 4 isoform b

    See proteins identical to NP_001291466.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant (1). The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC010899, AK300772, BC105000, BM676153, DA451606
    Conserved Domains (7) summary
    cd09545
    Location:860930
    SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
    smart00454
    Location:864924
    SAM; Sterile alpha motif
    cd10473
    Location:3152
    EphR_LBD_A; Ligand Binding Domain of Ephrin type-A Receptors
    cd00063
    Location:390481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:570827
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:511567
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cd05066
    Location:565831
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
  3. NM_004438.4NP_004429.1  ephrin type-A receptor 4 isoform a precursor

    See proteins identical to NP_004429.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC010899, BC105000, BM676153, DA451606
    Consensus CDS
    CCDS2447.1
    UniProtKB/TrEMBL
    A0A024R452
    UniProtKB/Swiss-Prot
    P54764
    UniProtKB/TrEMBL
    Q58F15
    Related
    ENSP00000281821, ENST00000281821
    Conserved Domains (7) summary
    cd09545
    Location:911981
    SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
    smart00454
    Location:915975
    SAM; Sterile alpha motif
    cd10482
    Location:30203
    EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
    cd00063
    Location:441532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:621878
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:562618
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cd05066
    Location:616882
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38 Primary Assembly

    Range
    221418027..221572290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246374.1XP_005246431.1  

    See proteins identical to XP_005246431.1

    UniProtKB/TrEMBL
    E9PG71
    Conserved Domains (6) summary
    cd10482
    Location:30203
    EphR_LBD_A4; Ligand Binding Domain of Ephrin type-A Receptor 4
    cd00063
    Location:441532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07714
    Location:621878
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:562618
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cd05066
    Location:616882
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    cl15755
    Location:911949
    SAM_superfamily; SAM (Sterile alpha motif )

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    222288287..222442879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 Alternate HuRef

    Range
    214137116..214291409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)