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    Irf7 interferon regulatory factor 7 [ Mus musculus (house mouse) ]

    Gene ID: 54123, updated on 24-Jun-2016
    Official Symbol
    Irf7provided by MGI
    Official Full Name
    interferon regulatory factor 7provided by MGI
    Primary source
    MGI:MGI:1859212
    See related
    Ensembl:ENSMUSG00000025498 Vega:OTTMUSG00000024538
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    7; 7 F5
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (141263183..141266499, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (148449088..148452300, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene microRNA 210 Neighboring gene PHD and ring finger domains 1 Neighboring gene cadherin-related family member 5 Neighboring gene secretin

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Chemically induced (ENU) (2) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    interferon-alpha production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-alpha production TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-beta production TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type I interferon production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of MyD88-dependent toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of MyD88-independent toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    type I interferon biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    interferon regulatory factor 7
    Names
    IRF-7

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252600.1NP_001239529.1  interferon regulatory factor 7 isoform 2

      See identical proteins and their annotated locations for NP_001239529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK152403, BQ033099, BY155234
      Consensus CDS
      CCDS57595.1
      UniProtKB/TrEMBL
      Q3TW14
      Related
      ENSMUSP00000095565, OTTMUSP00000029374, ENSMUST00000097952, OTTMUST00000060230
      Conserved Domains (2) summary
      cd00103
      Location:9124
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:209389
      IRF-3; Interferon-regulatory factor 3
    2. NM_001252601.1NP_001239530.1  interferon regulatory factor 7 isoform 3

      See identical proteins and their annotated locations for NP_001239530.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK002830, AK151470, BQ033099, BY155234, DT923384
      Consensus CDS
      CCDS57594.1
      UniProtKB/TrEMBL
      D3Z4U9
      Related
      ENSMUSP00000101644, OTTMUSP00000029375, ENSMUST00000106023, OTTMUST00000060231
      Conserved Domains (2) summary
      cd00103
      Location:9124
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:208388
      IRF-3; Interferon-regulatory factor 3
    3. NM_016850.3NP_058546.1  interferon regulatory factor 7 isoform 1

      See identical proteins and their annotated locations for NP_058546.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AK079685, BQ033099, BY155234
      Consensus CDS
      CCDS22005.1
      UniProtKB/Swiss-Prot
      P70434
      UniProtKB/TrEMBL
      Q542T3
      Related
      ENSMUSP00000026571, OTTMUSP00000029373, ENSMUST00000026571, OTTMUST00000060229
      Conserved Domains (2) summary
      cd00103
      Location:9124
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:240420
      IRF-3; Interferon-regulatory factor 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

      Range
      141263183..141266499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006536214.1XP_006536277.1  

      Conserved Domains (2) summary
      cd00103
      Location:9124
      IRF; Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The ...
      pfam10401
      Location:177357
      IRF-3; Interferon-regulatory factor 3

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      141056915..141060156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)