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    HOXB13 homeobox B13 [ Homo sapiens (human) ]

    Gene ID: 10481, updated on 7-Feb-2016
    Official Symbol
    HOXB13provided by HGNC
    Official Full Name
    homeobox B13provided by HGNC
    Primary source
    HGNC:HGNC:5112
    See related
    Ensembl:ENSG00000159184; HPRD:05210; MIM:604607; Vega:OTTHUMG00000159900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSGD
    Summary
    This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]
    Orthologs
    See HOXB13 in Epigenomics, MapViewer
    Location:
    17q21.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (48724763..48728749, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46802125..46806111, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene prostate cancer susceptibility candidate 2 Neighboring gene prostate cancer susceptibility candidate 1 Neighboring gene microRNA 3185 Neighboring gene uncharacterized LOC105371811 Neighboring gene uncharacterized LOC105371812

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer.
    NHGRI GWA Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    angiogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    epidermis development TAS
    Traceable Author Statement
    more info
    PubMed 
    epithelial cell maturation involved in prostate gland development IEA
    Inferred from Electronic Annotation
    more info
     
    prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of growth IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    response to wounding TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033789.1 RefSeqGene

      Range
      5001..8987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_771

    mRNA and Protein(s)

    1. NM_006361.5NP_006352.2  homeobox protein Hox-B13

      See identical proteins and their annotated locations for NP_006352.2

      Status: REVIEWED

      Source sequence(s)
      AY937237, BC070233
      Consensus CDS
      CCDS11536.1
      UniProtKB/TrEMBL
      Q4KR72
      UniProtKB/Swiss-Prot
      Q92826
      Related
      ENSP00000290295, OTTHUMP00000216942, ENST00000290295, OTTHUMT00000358087
      Conserved Domains (2) summary
      cd00086
      Location:217273
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam12284
      Location:10123
      HoxA13_N; Hox protein A13 N terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      48724763..48728749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      46868110..46872096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)