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    Jak2 Janus kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 16452, updated on 20-Aug-2016
    Official Symbol
    Jak2provided by MGI
    Official Full Name
    Janus kinase 2provided by MGI
    Primary source
    MGI:MGI:96629
    See related
    Ensembl:ENSMUSG00000024789
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fd17
    Orthologs
    Location:
    19 C1; 19 23.73 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (29251708..29313080)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (29326318..29387570)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5518 Neighboring gene predicted gene, 41829 Neighboring gene insulin-like 6 Neighboring gene relaxin 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    acetylcholine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    growth hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone kinase activity (H3-Y41 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    histone kinase activity (H3-Y41 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor substrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-12 receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    type 1 angiotensin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    JAK-STAT cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    JAK-STAT cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    JAK-STAT cascade involved in growth hormone signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    JAK-STAT cascade involved in growth hormone signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    JAK-STAT cascade involved in growth hormone signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    STAT protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of JAK2 kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of MAPKK activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
     
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to dexamethasone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to interleukin-3 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    enzyme linked receptor protein signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
     
    growth hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    histone H3-Y41 phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    host programmed cell death induced by symbiont IDA
    Inferred from Direct Assay
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    interferon-gamma-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-12-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    mammary gland epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mineralocorticoid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of growth factor dependent skeletal muscle satellite cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of growth hormone receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nitric-oxide synthase biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein import into nucleus, translocation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
     
    positive regulation of tyrosine phosphorylation of Stat3 protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tyrosine phosphorylation of Stat5 protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    response to granulocyte macrophage colony-stimulating factor NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to hydroperoxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to interleukin-12 ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tyrosine phosphorylation of Stat1 protein ISO
    Inferred from Sequence Orthology
    more info
     
    tyrosine phosphorylation of Stat3 protein ISO
    Inferred from Sequence Orthology
    more info
     
    tyrosine phosphorylation of Stat5 protein ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    tyrosine-protein kinase JAK2
    Names
    JAK-2
    NP_001041642.1
    NP_032439.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048177.2NP_001041642.1  tyrosine-protein kinase JAK2

      See identical proteins and their annotated locations for NP_001041642.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC119228, AK087255, BC054807, BE981299, BF019856, BG068603, CD363707, CJ046359
      Consensus CDS
      CCDS37950.1
      UniProtKB/Swiss-Prot
      Q62120
      UniProtKB/TrEMBL
      G5E852
      Related
      ENSMUSP00000025705, ENSMUST00000025705
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:38270
      B41; Band 4.1 homologues
      pfam07714
      Location:8491119
      Pkinase_Tyr; Protein tyrosine kinase
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    2. NM_008413.3NP_032439.2  tyrosine-protein kinase JAK2

      See identical proteins and their annotated locations for NP_032439.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC119228, AK087255, BC054807, BE981299, BF019856, BG068603, CD363707, CJ046359
      Consensus CDS
      CCDS37950.1
      UniProtKB/Swiss-Prot
      Q62120
      UniProtKB/TrEMBL
      G5E852
      Related
      ENSMUSP00000064394, ENSMUST00000065796
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:38270
      B41; Band 4.1 homologues
      pfam07714
      Location:8491119
      Pkinase_Tyr; Protein tyrosine kinase
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      29251708..29313080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526713.3XP_006526776.1  

      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:38270
      B41; Band 4.1 homologues
      pfam07714
      Location:8041074
      Pkinase_Tyr; Protein tyrosine kinase
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd14205
      Location:7991082
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cl21453
      Location:548761
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006526715.3XP_006526778.1  

      Conserved Domains (5) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:38270
      B41; Band 4.1 homologues
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd14473
      Location:152261
      FERM_B-lobe; FERM domain B-lobe
      cl21453
      Location:545592
      PKc_like; Protein Kinases, catalytic domain
    3. XM_011247155.2XP_011245457.1  

      See identical proteins and their annotated locations for XP_011245457.1

      UniProtKB/TrEMBL
      G5E852
      Conserved Domains (6) summary
      cd10379
      Location:386482
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      smart00295
      Location:38270
      B41; Band 4.1 homologues
      pfam07714
      Location:8491119
      Pkinase_Tyr; Protein tyrosine kinase
      cd13333
      Location:266386
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:545806
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:8441127
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    4. XM_017318068.1XP_017173557.1  

    5. XM_006526714.3XP_006526777.1  

      Conserved Domains (5) summary
      cd10379
      Location:190286
      SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
      pfam07714
      Location:653923
      Pkinase_Tyr; Protein tyrosine kinase
      cd13333
      Location:70190
      FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
      cd05078
      Location:349610
      PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
      cd14205
      Location:648931
      PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2