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    Ptbp2 polypyrimidine tract binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 56195, updated on 3-Jul-2016
    Official Symbol
    Ptbp2provided by MGI
    Official Full Name
    polypyrimidine tract binding protein 2provided by MGI
    Primary source
    MGI:MGI:1860489
    See related
    Ensembl:ENSMUSG00000028134 Vega:OTTMUSG00000054606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ptb2; nPTB; brPTB
    Orthologs
    Location:
    3; 3 G1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (119718741..119783799, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (119421660..119486306, complement)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40131 Neighboring gene ribosomal protein S20 pseudogene Neighboring gene predicted gene, 38548 Neighboring gene ribonucleotide reductase M2 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splice site selection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA splice site selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    polypyrimidine tract-binding protein 2
    Names
    RRM-type RNA-binding protein brPTB
    brain-enriched PTB
    brain-enriched polypyrimidine tract-binding protein
    neural polypyrimidine tract-binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310711.1NP_001297640.1  polypyrimidine tract-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001297640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC111029, AK013734, AK033964, AK135738
      Consensus CDS
      CCDS80010.1
      UniProtKB/Swiss-Prot
      Q91Z31
      Related
      ENSMUSP00000143510, OTTMUSP00000071642, ENSMUST00000200097, OTTMUST00000135359
      Conserved Domains (5) summary
      cd12693
      Location:178273
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12696
      Location:325431
      RRM3_PTBP2; RNA recognition motif 3 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      cd12702
      Location:452531
      RRM4_PTBP2; RNA recognition motif 4 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      cd12778
      Location:58139
      RRM1_PTBP2; RNA recognition motif 1 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      TIGR01649
      Location:57531
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    2. NM_019550.2NP_062423.1  polypyrimidine tract-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_062423.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC111029, AK137348
      Consensus CDS
      CCDS38616.1
      UniProtKB/Swiss-Prot
      Q91Z31
      Related
      ENSMUSP00000029780, ENSMUST00000029780
      Conserved Domains (5) summary
      cd12693
      Location:178273
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12696
      Location:325431
      RRM3_PTBP2; RNA recognition motif 3 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      cd12702
      Location:452532
      RRM4_PTBP2; RNA recognition motif 4 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      cd12778
      Location:58139
      RRM1_PTBP2; RNA recognition motif 1 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      TIGR01649
      Location:57532
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      119718741..119783799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501732.1XP_006501795.1  

      See identical proteins and their annotated locations for XP_006501795.1

      Conserved Domains (5) summary
      cd12693
      Location:178273
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12696
      Location:330436
      RRM3_PTBP2; RNA recognition motif 3 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      cd12702
      Location:457536
      RRM4_PTBP2; RNA recognition motif 4 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      cd12778
      Location:58139
      RRM1_PTBP2; RNA recognition motif 1 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      TIGR01649
      Location:57536
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family
    2. XM_006501731.1XP_006501794.1  

      See identical proteins and their annotated locations for XP_006501794.1

      Conserved Domains (5) summary
      cd12693
      Location:178273
      RRM2_PTBP1_like; RNA recognition motif 2 in polypyrimidine tract-binding protein 1 (PTB or hnRNP I) and similar proteins
      cd12696
      Location:330436
      RRM3_PTBP2; RNA recognition motif 3 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      cd12702
      Location:457537
      RRM4_PTBP2; RNA recognition motif 4 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      cd12778
      Location:58139
      RRM1_PTBP2; RNA recognition motif 1 in vertebrate polypyrimidine tract-binding protein 2 (PTBP2)
      TIGR01649
      Location:57537
      hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family

    RNA

    1. XR_375549.1 RNA Sequence

    2. XR_001783718.1 RNA Sequence

    3. XR_375550.2 RNA Sequence

    4. XR_001783719.1 RNA Sequence