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    SCD5 stearoyl-CoA desaturase 5 [ Homo sapiens (human) ]

    Gene ID: 79966, updated on 26-Jun-2015
    Official Symbol
    SCD5provided by HGNC
    Official Full Name
    stearoyl-CoA desaturase 5provided by HGNC
    Primary source
    HGNC:HGNC:21088
    See related
    Ensembl:ENSG00000145284; HPRD:09756; MIM:608370; Vega:OTTHUMG00000130293
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCD2; SCD4; ACOD4; FADS4; HSCD5
    Summary
    Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]
    Orthologs
    See SCD5 in Epigenomics, MapViewer
    Location:
    4q21.22
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (82629537..82798857, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83550690..83720010, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 11 pseudogene Neighboring gene long intergenic non-protein coding RNA 575 Neighboring gene PQ loop repeat containing 1 pseudogene 2 Neighboring gene microRNA 575 Neighboring gene SEC31 homolog A (S. cerevisiae) Neighboring gene THAP9 antisense RNA 1 Neighboring gene THAP domain containing 9

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Clone Names

    • FLJ21032

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    stearoyl-CoA 9-desaturase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    stearoyl-CoA desaturase 5
    Names
    stearoyl-CoA desaturase 5
    acyl-CoA-desaturase 4
    stearoyl-CoA 9-desaturase
    stearoyl-CoA desaturase 4
    NP_001032671.2
    NP_079182.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037582.2NP_001032671.2  stearoyl-CoA desaturase 5 isoform a

      See identical proteins and their annotated locations for NP_001032671.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encoded the longer isoform (A).
      Source sequence(s)
      AF389338, BC048971, CB155881, DB479400, DR763368
      Consensus CDS
      CCDS34024.1
      UniProtKB/Swiss-Prot
      Q86SK9
      UniProtKB/TrEMBL
      Q86UC8
      Related
      ENSP00000316329, OTTHUMP00000160803, ENST00000319540, OTTHUMT00000252635
      Conserved Domains (1) summary
      cd03505
      Location:71311
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    2. NM_024906.2NP_079182.2  stearoyl-CoA desaturase 5 isoform b

      See identical proteins and their annotated locations for NP_079182.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the 3' coding region, compared to variant 1, which result in a protein (isoform B) with a shorter and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AC073413
      Consensus CDS
      CCDS3595.1
      UniProtKB/Swiss-Prot
      Q86SK9
      Related
      ENSP00000273908, OTTHUMP00000160804, ENST00000273908, OTTHUMT00000252636
      Conserved Domains (1) summary
      cd03505
      Location:71159
      Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      Range
      82629537..82798857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      83527197..83696517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)