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    PXN paxillin [ Homo sapiens (human) ]

    Gene ID: 5829, updated on 22-Aug-2016
    Official Symbol
    PXNprovided by HGNC
    Official Full Name
    paxillinprovided by HGNC
    Primary source
    HGNC:HGNC:9718
    See related
    Ensembl:ENSG00000089159 MIM:602505; Vega:OTTHUMG00000169169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
    Orthologs
    Location:
    12q24.31
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (120210439..120265771, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120648242..120703574, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene GCN1, eIF2 alpha kinase activator homolog Neighboring gene microRNA 4498 Neighboring gene ribosomal protein lateral stalk subunit P0 Neighboring gene PXN antisense RNA 1 Neighboring gene ribosomal protein S20 pseudogene 31 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 pseudogene 1 Neighboring gene RNA, U4 small nuclear 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env SLIT2N, an active fragment of SLIT2, inhibits M-tropic HIV-1 gp120-induced Src signaling and activation of its downstream targets Pyk2, CDC42, Rac1, and paxillin in immature monocyte-derived dendritic cells PubMed
    Nef nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
    nef The Nef/hnRNPK/PKC-delta/Hck protein complex increases paxillin phosphorylation at Y118 and activates and secretes TACE through Erk1/2 activation PubMed
    Tat tat Endothelial cell adherent to HIV-1 Tat induces upregulation of VEGFR2, integrin beta(3) subunit, pp60src and recruits VEGFR2, integrin beta(3) subunit, paxillin, focal adhesion kinase, and pp60src to ventral plasma membranes PubMed
    tat HIV-1 Tat stimulates the phosphorylation of paxillin and its association with RAFTK, an effect linked to Tat-induced angiogenesis and AIDS-related Kaposi's sarcoma PubMed
    matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ16691

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    integrin binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    vinculin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to reactive oxygen species IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    growth hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    muscle contraction TAS
    Traceable Author Statement
    more info
     
    signal complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule associated complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    stress fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    paxillin
    Names
    testicular tissue protein Li 134

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029820.1 RefSeqGene

      Range
      5001..60333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080855.2NP_001074324.1  paxillin isoform 2

      See identical proteins and their annotated locations for NP_001074324.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional in-frame coding exon compared to variant 1. This results in a longer isoform (2, also known as isoform beta) containing a 34 aa protein segment not found in isoform 1.
      Source sequence(s)
      AA922640, BC144410, BU500419, BX648777, DB472926
      Consensus CDS
      CCDS44997.1
      UniProtKB/Swiss-Prot
      P49023
      UniProtKB/TrEMBL
      A0A140VJQ8
      Related
      ENSP00000228307, OTTHUMP00000240291, ENST00000228307, OTTHUMT00000402679
      Conserved Domains (5) summary
      cd09338
      Location:476528
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:417468
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:535586
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      pfam03535
      Location:54253
      Paxillin; Paxillin family
      cd09336
      Location:358410
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    2. NM_001243756.1NP_001230685.1  paxillin isoform 3

      See identical proteins and their annotated locations for NP_001230685.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in a longer isoform (3, also known as isoform gamma) containing a 48 aa protein segment not found in isoform 1.
      Source sequence(s)
      AA922640, BC136794, BC144410, BU500419, BX648777, D86863, DB472926
      Consensus CDS
      CCDS58281.1
      UniProtKB/Swiss-Prot
      P49023
      Related
      ENSP00000267257, ENST00000267257
      Conserved Domains (5) summary
      cd09338
      Location:490542
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:431482
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:549600
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:372424
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54253
      Paxillin; Paxillin family
    3. NM_002859.3NP_002850.2  paxillin isoform 1

      See identical proteins and their annotated locations for NP_002850.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as isoform alpha).
      Source sequence(s)
      AA922640, BC136794, BC144410, BU500419, BX648777, DB472926
      Consensus CDS
      CCDS44996.1
      UniProtKB/Swiss-Prot
      P49023
      Related
      ENSP00000391283, OTTHUMP00000240317, ENST00000424649, OTTHUMT00000402713
      Conserved Domains (5) summary
      cd09338
      Location:442494
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:383434
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:501552
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      cd09336
      Location:324376
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:54253
      Paxillin; Paxillin family
    4. NM_025157.4NP_079433.3  paxillin isoform 4

      See identical proteins and their annotated locations for NP_079433.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (4) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA922640, BC136794, BC144410, BU500419, BX648777, DA565031
      Consensus CDS
      CCDS44998.1
      UniProtKB/Swiss-Prot
      P49023
      Related
      ENSP00000395536, OTTHUMP00000240326, ENST00000458477, OTTHUMT00000402736
      Conserved Domains (4) summary
      cd09338
      Location:309361
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09336
      Location:191243
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:1120
      Paxillin; Paxillin family
      cl02475
      Location:250301
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      120210439..120265771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006719532.1XP_006719595.1  

      Related
      ENSP00000489840, OTTHUMP00000282145, ENST00000637617, OTTHUMT00000489566
      Conserved Domains (5) summary
      cd09338
      Location:10141066
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:9551006
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:10731124
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      pfam03535
      Location:54253
      Paxillin; Paxillin family
      cd09336
      Location:896948
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    2. XM_017019734.1XP_016875223.1  

    3. XM_011538622.1XP_011536924.1  

      See identical proteins and their annotated locations for XP_011536924.1

      Conserved Domains (5) summary
      cd09338
      Location:881933
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:822873
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:940991
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      pfam03535
      Location:1120
      Paxillin; Paxillin family
      cd09336
      Location:763815
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    4. XM_017019743.1XP_016875232.1  

      Conserved Domains (4) summary
      cd09338
      Location:309361
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09336
      Location:191243
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      pfam03535
      Location:1120
      Paxillin; Paxillin family
      cl02475
      Location:250301
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    5. XM_011538623.1XP_011536925.1  

      See identical proteins and their annotated locations for XP_011536925.1

      Conserved Domains (5) summary
      cd09338
      Location:881933
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:822873
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:940991
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      pfam03535
      Location:1120
      Paxillin; Paxillin family
      cd09336
      Location:763815
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    6. XM_006719534.1XP_006719597.1  

      See identical proteins and their annotated locations for XP_006719597.1

      Conserved Domains (5) summary
      cd09338
      Location:881933
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:822873
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:940991
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      pfam03535
      Location:1120
      Paxillin; Paxillin family
      cd09336
      Location:763815
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    7. XM_017019741.1XP_016875230.1  

      Related
      ENSP00000443887, OTTHUMP00000240327, ENST00000536957, OTTHUMT00000402737
    8. XM_017019728.1XP_016875217.1  

    9. XM_017019727.1XP_016875216.1  

    10. XM_017019731.1XP_016875220.1  

    11. XM_017019742.1XP_016875231.1  

    12. XM_017019739.1XP_016875228.1  

    13. XM_017019740.1XP_016875229.1  

    14. XM_017019738.1XP_016875227.1  

    15. XM_017019737.1XP_016875226.1  

    16. XM_017019736.1XP_016875225.1  

    17. XM_017019735.1XP_016875224.1  

    18. XM_017019733.1XP_016875222.1  

    19. XM_017019729.1XP_016875218.1  

    20. XM_017019726.1XP_016875215.1  

    21. XM_006719535.3XP_006719598.1  

      See identical proteins and their annotated locations for XP_006719598.1

      Conserved Domains (5) summary
      cd09338
      Location:881933
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:822873
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:940991
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      pfam03535
      Location:1120
      Paxillin; Paxillin family
      cd09336
      Location:763815
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    22. XM_006719536.2XP_006719599.1  

      See identical proteins and their annotated locations for XP_006719599.1

      Conserved Domains (5) summary
      cd09338
      Location:881933
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09407
      Location:822873
      LIM2_Paxillin; The second LIM domain of paxillin
      cd09411
      Location:940991
      LIM4_Paxillin; The fourth LIM domain of Paxillin
      pfam03535
      Location:1120
      Paxillin; Paxillin family
      cd09336
      Location:763815
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
    23. XM_005253917.3XP_005253974.1  

      Conserved Domains (3) summary
      cd09338
      Location:288340
      LIM3_Paxillin_like; The third LIM domain of the paxillin like protein family
      cd09336
      Location:170222
      LIM1_Paxillin_like; The first LIM domain of the paxillin like protein family
      cl02475
      Location:229280
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    24. XM_017019730.1XP_016875219.1  

    25. XM_017019732.1XP_016875221.1  

    RNA

    1. XR_001748832.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      120616253..120671571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)