Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    SULT1A1 sulfotransferase family 1A member 1 [ Homo sapiens (human) ]

    Gene ID: 6817, updated on 18-Aug-2016
    Official Symbol
    SULT1A1provided by HGNC
    Official Full Name
    sulfotransferase family 1A member 1provided by HGNC
    Primary source
    HGNC:HGNC:11453
    See related
    Ensembl:ENSG00000196502 HPRD:01372; MIM:171150; Vega:OTTHUMG00000131765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; HAST1/HAST2
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    16p12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (28605587..28623586, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28616908..28634907, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene SAGA complex associated factor 29 Neighboring gene sulfotransferase family 1A member 2 Neighboring gene uncharacterized LOC107984835 Neighboring gene nuclear pore complex interacting protein family member B8 Neighboring gene eukaryotic translation initiation factor 3 subunit C Neighboring gene cell division cycle 37 pseudogene 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    NHGRI GWA Catalog
    Common variants at five new loci associated with early-onset inflammatory bowel disease.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC5163, MGC131921

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aryl sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aryl sulfotransferase activity TAS
    Traceable Author Statement
    more info
     
    flavonol 3-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    steroid sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    3'-phosphoadenosine 5'-phosphosulfate metabolic process TAS
    Traceable Author Statement
    more info
     
    amine metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    catecholamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    estrogen metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    flavonoid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    sulfation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    sulfotransferase 1A1
    Names
    P-PST 1
    aryl sulfotransferase 1
    phenol-sulfating phenol sulfotransferase 1
    sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
    thermostable phenol sulfotransferase1
    ts-PST
    NP_001046.2
    NP_803565.1
    NP_803566.1
    NP_803878.1
    NP_803880.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028128.1 RefSeqGene

      Range
      19218..22959
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001055.3NP_001046.2  sulfotransferase 1A1 isoform a

      See identical proteins and their annotated locations for NP_001046.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the predominant transcript. Variants 1, 2, 3 and 4 encode the same isoform (a).
      Source sequence(s)
      BC000923, BG482944, BM984308, U26309
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225
      Related
      ENSP00000321988, OTTHUMP00000162569, ENST00000314752, OTTHUMT00000254694
      Conserved Domains (1) summary
      pfam00685
      Location:38287
      Sulfotransfer_1; Sulfotransferase domain
    2. NM_177529.2NP_803565.1  sulfotransferase 1A1 isoform a

      See identical proteins and their annotated locations for NP_803565.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
      Source sequence(s)
      AJ007418, BG482944, BM927749, BM984308, BT007324
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225
      Related
      ENSP00000456459, OTTHUMP00000254105, ENST00000566189, OTTHUMT00000430987
      Conserved Domains (1) summary
      pfam00685
      Location:38287
      Sulfotransfer_1; Sulfotransferase domain
    3. NM_177530.2NP_803566.1  sulfotransferase 1A1 isoform a

      See identical proteins and their annotated locations for NP_803566.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
      Source sequence(s)
      AC020765, AJ007418, BG990719, BM984308, BT007324, CV023878
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225
      Related
      ENSP00000378971, ENST00000395607
      Conserved Domains (1) summary
      pfam00685
      Location:38287
      Sulfotransfer_1; Sulfotransferase domain
    4. NM_177534.2NP_803878.1  sulfotransferase 1A1 isoform a

      See identical proteins and their annotated locations for NP_803878.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
      Source sequence(s)
      AC020765, BM984308, BT007324, U26309
      Consensus CDS
      CCDS32420.1
      UniProtKB/Swiss-Prot
      P50225
      Related
      ENSP00000457912, OTTHUMP00000254103, ENST00000569554, OTTHUMT00000430985
      Conserved Domains (1) summary
      pfam00685
      Location:38287
      Sulfotransfer_1; Sulfotransferase domain
    5. NM_177536.3NP_803880.1  sulfotransferase 1A1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1, which causes the predicted protein (isoform b) to be shorter than isoform a. The predicted ORF of this rare transcript has not been experimentally confirmed.
      Source sequence(s)
      AC020765, BM984308
      Consensus CDS
      CCDS10637.1
      UniProtKB/Swiss-Prot
      P50225
      Related
      ENSP00000329399, OTTHUMP00000162568, ENST00000350842, OTTHUMT00000254693
      Conserved Domains (1) summary
      pfam00685
      Location:47209
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      28605587..28623586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023613.1XP_016879102.1  

      Conserved Domains (1) summary
      pfam00685
      Location:38287
      Sulfotransfer_1; Sulfotransferase domain
    2. XM_017023612.1XP_016879101.1  

      Conserved Domains (1) summary
      pfam00685
      Location:38287
      Sulfotransfer_1; Sulfotransferase domain
    3. XM_017023611.1XP_016879100.1  

      Related
      ENSP00000378972, ENST00000395609
      Conserved Domains (1) summary
      pfam00685
      Location:38287
      Sulfotransfer_1; Sulfotransferase domain
    4. XM_017023607.1XP_016879096.1  

    5. XM_017023606.1XP_016879095.1  

      Conserved Domains (1) summary
      pfam00685
      Location:38287
      Sulfotransfer_1; Sulfotransferase domain
    6. XM_017023605.1XP_016879094.1  

    7. XM_017023604.1XP_016879093.1  

    8. XM_017023608.1XP_016879097.1  

    9. XM_017023609.1XP_016879098.1  

    10. XM_017023610.1XP_016879099.1  

    RNA

    1. XR_001751973.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      29629153..29647182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)